Histological transformation of ALK rearranged adenocarcinoma into small cell lung cancer: A new mechanism of resistance to ALK inhibitors

被引：60

作者：

Levacq, Delphine ^{[1
]}

D'Haene, Nicky ^{[2
]}

de Wind, Roland ^{[3
]}

Remmelink, Myriam ^{[2
]}

Berghmans, Thierry ^{[4
]}

机构：

[1] Univ Libre Bruxelles, Inst Jules Bordet, Dept Med Oncol, Brussels, Belgium

[2] Univ Libre Bruxelles, Dept Pathol, Hop Erasme, Brussels, Belgium

[3] Univ Libre Bruxelles, Inst Jules Bordet, Dept Pathol, Brussels, Belgium

[4] Univ Libre Bruxelles, Inst Jules Bordet, Dept Intens Care & Oncol Emergencies & Thorac Onc, Brussels, Belgium

来源：

LUNG CANCER | 2016年 / 102卷

关键词：

ALK translocation; Lung neoplasms; Small cell cancer transformation; ACQUIRED-RESISTANCE; KINASE INHIBITORS; EML4-ALK FUSION; CRIZOTINIB; CHEMOTHERAPY; PATTERNS; MUTATION;

D O I：

10.1016/j.lungcan.2016.10.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Various mechanisms of resistance to ALK inhibitors in ALK rearranged adenocarcinomas are reported including secondary gatekeeper mutations, bypass signaling or ALK amplifications as the commonest ones. We report a new mechanism of resistance with transformation of adenocarcinoma into small cell lung cancer. A 53-year-old non-smoker woman, experienced cancer progression after two lines of ALK inhibitors. A new biopsy showed a small cell lung cancer. FISH revealed persistent ALK rearrangement with an atypical pattern and complete loss of the 5' region of the ALK gene. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：38 / 41

页数：4

共 22 条

[1]

[Anonymous], BELGIAN J MED ONCOL

[2] Neuroendocrine phenotype as an acquired resistance mechanism in ALK-rearranged lung adenocarcinoma [J].

Caumont, Charline ;

Veillon, Remi ;

Gros, Audrey ;

Laharanne, Elodie ;

Begueret, Hugues ;

Merlio, Jean-Philippe .

LUNG CANCER, 2016, 92 :15-18

[3] A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib [J].

Cha, Yoon Jin ;

Cho, Byoung Chul ;

Kim, Hye Ryun ;

Lee, Hye-Jeong ;

Shim, Hyo Sup .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (05) :E55-E58

[4] Clinical Validation of Targeted Next Generation Sequencing for Colon and Lung Cancers [J].

D'Haene, Nicky ;

Le Mercier, Marie ;

De Neve, Nancy ;

Blanchard, Oriane ;

Delaunoy, Melanie ;

El Housni, Hakim ;

Dessars, Barbara ;

Heimann, Pierre ;

Remmelink, Myriam ;

Demetter, Pieter ;

Tejpar, Sabine ;

Salmon, Isabelle .

PLOS ONE, 2015, 10 (09)

[5] Incidence and patterns of ALK FISH abnormalities seen in a large unselected series of lung carcinomas [J].

Dai, Zunyan ;

Kelly, JoAnn C. ;

Meloni-Ehrig, Aurelia ;

Slovak, Marilyn L. ;

Boles, Debra ;

Christacos, Nicole C. ;

Bryke, Christine R. ;

Schonberg, Steven A. ;

Otani-Rosa, Jennifer ;

Pan, Qiulu ;

Ho, Albert K. ;

Sanders, Heather R. ;

Zhang, Zhong J. ;

Jones, Dan ;

Mowrey, Philip N. .

MOLECULAR CYTOGENETICS, 2012, 5

[6] Transformation to SCLC after Treatment with the ALK Inhibitor Alectinib [J].

Fujita, Shiro ;

Masago, Katsuhiro ;

Katakami, Nobuyuki ;

Yatabe, Yasushi .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (06) :E67-E72

[7] Clinical Implications of Variant ALK FISH Rearrangement Patterns [J].

Gao, Xin ;

Sholl, Lynette M. ;

Nishino, Mizuki ;

Heng, Jennifer C. ;

Jaenne, Pasi A. ;

Oxnard, Geoffrey R. .

JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (11) :1648-1652

[8] Comprehensive genomic profiles of small cell lung cancer [J].

George, Julie ;

Lim, Jing Shan ;

Jang, Se Jin ;

Cun, Yupeng ;

Ozretic, Luka ;

Kong, Gu ;

Leenders, Frauke ;

Lu, Xin ;

Fernandez-Cuesta, Lynnette ;

Bosco, Graziella ;

Mueller, Christian ;

Dahmen, Ilona ;

Jahchan, Nadine S. ;

Park, Kwon-Sik ;

Yang, Dian ;

Karnezis, Anthony N. ;

Vaka, Dedeepya ;

Torres, Angela ;

Wang, Maia Segura ;

Korbel, Jan O. ;

Menon, Roopika ;

Chun, Sung-Min ;

Kim, Deokhoon ;

Wilkerson, Matt ;

Hayes, Neil ;

Engelmann, David ;

Puetzer, Brigitte ;

Bos, Marc ;

Michels, Sebastian ;

Vlasic, Ignacija ;

Seidel, Danila ;

Pinther, Berit ;

Schaub, Philipp ;

Becker, Christian ;

Altmueller, Janine ;

Yokota, Jun ;

Kohno, Takashi ;

Iwakawa, Reika ;

Tsuta, Koji ;

Noguchi, Masayuki ;

Muley, Thomas ;

Hoffmann, Hans ;

Schnabel, Philipp A. ;

Petersen, Iver ;

Chen, Yuan ;

Soltermann, Alex ;

Tischler, Verena ;

Choi, Chang-min ;

Kim, Yong-Hee ;

Massion, Pierre P. .

NATURE, 2015, 524 (7563) :47-53

[9] Mechanisms of resistance to EGFR tyrosine kinase inhibitors [J].

Huang, Lihua ;

Fu, Liwu .

ACTA PHARMACEUTICA SINICA B, 2015, 5 (05) :390-401

[10] Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing [J].

Iwakawa, Reika ;

Kohno, Takashi ;

Totoki, Yasushi ;

Shibata, Tatsuhiro ;

Tsuchihara, Katsuya ;

Mimaki, Sachiyo ;

Tsuta, Koji ;

Narita, Yoshitaka ;

Nishikawa, Ryo ;

Noguchi, Masayuki ;

Harris, Curtis C. ;

Robles, Ana I. ;

Yamaguchi, Rui ;

Imoto, Seiya ;

Miyano, Satoru ;

Totsuka, Hirohiko ;

Yoshida, Teruhiko ;

Yokota, Jun .

CARCINOGENESIS, 2015, 36 (06) :616-621

← 1 2 3 →