Cloning and characterization of the Drosophila presenilin homologue

被引：60

作者：

Boulianne, GL

LivneBar, I

Humphreys, JM

Liang, Y

Lin, C

Rogaev, E

StGeorgeHyslop, P

机构：

[1] UNIV TORONTO,HOSP SICK CHILDREN,DEPT PHYSIOL & ZOOL,PROGRAM DEV BIOL,TORONTO,ON M5G 1X8,CANADA

[2] TORONTO HOSP,DEPT MED NEUROL,CTR RES NEURODEGENERAT DIS,TORONTO,ON M5S 3H2,CANADA

[3] UNIV TORONTO,DEPT MED,TORONTO,ON M5S 3H2,CANADA

来源：

NEUROREPORT | 1997年 / 8卷 / 04期

关键词：

Alzheimer's disease; Drosophila; presenilin;

D O I：

10.1097/00001756-199703030-00041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MUTATIONS in two genes, PS1 and PS2, coding for the presenilins, have been linked to the early onset form of familial Alzheimer's disease (AD). Here we report the identification of a Drosophila melanogaster homologue of human PS genes, Dps, which maps to band 77B-C on chromosome 3 and is expressed at multiple developmental stages. The predicted amino acid sequence of the Dps product is 53% identical to human presenilins, with the greatest similarity in the putative transmembrane domains, the hydrophobic domains at the beginning and the end of the cytoplasmic TM6-TM7 loop and the C-terminus. Analysis of Dps in a genetically tractable model system such as Drosophila may provide insight into the mechanisms of Alzheimer's disease (AD) necessary for the development of rational therapeutic approaches.

引用

页码：1025 / 1029

页数：5

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