Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

被引：0
|
作者：
Kwok, Marwan [1 ]
Davies, Nicholas [1 ]
Agathanggelou, Angelo [1 ]
Smith, Edward [1 ]
Petermann, Eva [1 ]
Yates, Eliot [1 ]
Brown, Jeffrey [2 ]
Lau, Alan [3 ]
Stankovic, Tatjana [1 ]
机构：
[1] Univ Birmingham, Sch Canc Sci, Birmingham B15 2TT, W Midlands, England
[2] AstraZeneca, Oncol IMed, Waltham, MA USA
[3] AstraZeneca, R&D Oncol IMed, Alderley Pk, Cheshire, England
来源：
LANCET | 2015年 / 385卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：58 / 58
页数：1
相关论文
共 50 条
  • [1] Synthetic Lethality In CLL With DNA Damage Response Defect By Targeting ATR Pathway
    Stankovic, Tatjana
    Nicholas, Davies
    Kwok, Marwan
    Smith, Edward
    Yates, Eliot
    Agathanggelou, Angelo
    Jeff, Brown
    Lau, Alan
    BLOOD, 2013, 122 (21)
  • [2] Targeting the DNA Damage Response Pathway by Combination of ATR and PARP Inhibition Imparts Synthetic Lethality to Cervical Cancer Cells
    Hill, Marlee
    Elayapillai, Sugantha Priya
    Hannafon, Bethany N.
    Moxley, Katherine
    AMERICAN JOURNAL OF PATHOLOGY, 2021, 191 (10 S): : S1 - S1
  • [3] Exploring the DNA damage response pathway for synthetic lethality
    Xin Xu
    Somaira Nowsheen
    Min Deng
    Genome Instability & Disease, 2023, 4 (2) : 98 - 120
  • [4] Comprehensive interrogation of synthetic lethality in the DNA damage response
    John Fielden
    Sebastian M. Siegner
    Danielle N. Gallagher
    Markus S. Schröder
    Maria Rosaria Dello Stritto
    Simon Lam
    Lena Kobel
    Moritz F. Schlapansky
    Stephen P. Jackson
    Petr Cejka
    Marco Jost
    Jacob E. Corn
    Nature, 2025, 640 (8060) : 1093 - 1102
  • [5] Targeting ATR in DNA damage response and cancer therapeutics
    Fokas, Emmanouil
    Prevo, Remko
    Hammond, Ester M.
    Brunner, Thomas B.
    McKenna, W. Gillies
    Muschel, Ruth J.
    CANCER TREATMENT REVIEWS, 2014, 40 (01) : 109 - 117
  • [6] Investigation of synthetic lethality gene pairs in the DNA damage response pathway in response to immunotherapy in pan-cancer
    Huang, Hongyan
    Liu, Miao
    Zhang, Ding
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [7] Targeting the DNA damage response in disease: exploiting synthetic lethality between POLtheta and BRCA1
    Loizou, Joanna
    JOURNAL OF PATHOLOGY, 2023, 261 (SUPPL1): : S11 - S12
  • [8] Testicular and sperm DNA damage after treatment with fludarabine for chronic lymphocytic leukaemia
    Chatterjee, R
    Haines, GA
    Perera, DMD
    Goldstone, A
    Morris, ID
    HUMAN REPRODUCTION, 2000, 15 (04) : 762 - 766
  • [9] Targeting DNA-damage response pathway with a novel nano-liposomal ATR inhibitor in solid tumors
    Koshkaryev, Alexander
    Alkan, Ozan
    Geng, Bolin
    Luus, Lia
    Raue, Andreas
    Kamoun, Walid
    Tipparaju, Suresh
    Kirpotin, Dmitri
    Drummond, Daryl
    CANCER RESEARCH, 2019, 79 (13)
  • [10] Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?
    Lazo, Pedro A.
    CANCERS, 2022, 14 (16)
12345