Facile one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-one catalyzed by Zn(NH2SO3)2

被引：30

作者：

Zhang, M ^{[1
]}

Li, YQ ^{[1
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 610632, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Biginelli reaction; catalyst; zinc sulfamate;

D O I：

10.1080/00397910500464228

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMS) from aromatic aldehydes, beta-keto ester, and urea ( or thiourea) in refluxing ethanol using zinc sulfamate as a catalyst is first described here. Compared to the classical Biginelli reaction, this new method consistently has the advantages of good yields (76-96%), short reaction time (2-5h), no corrosion of equipment, ease of manipulation, and low-cost catalyst.

引用

页码：835 / 841

页数：7

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