Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues

被引：70

作者：

Jubie, Selvaraj ^{[1
]}

Ramesh, Patil Nilesh ^{[1
]}

Dhanabal, Palanichamy ^{[2
]}

Kalirajan, Rajagopal ^{[1
]}

Muruganantham, Nithyanantham ^{[2
]}

Antony, Anthoniswamy Shanish ^{[3
]}

机构：

[1] JSS Coll Pharm, Dept Pharmaceut Chem, Ooty 643001, Tamilnadu, India

[2] JSS Coll Pharm, Dept Phytopharm & Phytomed, Ooty 643001, Tamilnadu, India

[3] JSS Coll Pharm, Dept Pharmacol, Ooty 643001, Tamilnadu, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 54卷

关键词：

Spirulina platensis; Stearic acid; Antidepressant; Estimation of dopamine antimicrobial;

D O I：

10.1016/j.ejmech.2012.06.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stearic acid, a saturated fatty acid was isolated from the microalga Spirulina platensis. Some novel stearic acid analogues having 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole are synthesized and characterized by IR, NMR and mass spectral analysis. All the synthesized compounds were screened for antimicrobial activity by using cup plate method. The synthesized compounds have been further screened for their antidepressant activity in swiss albino mice by forced swim test (FST), midbrain dopamine has been estimated and quantified. All the compounds showed good antimicrobial activity and compound 6 showed significant antidepressant activity. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：931 / 935

页数：5

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