Retrograde transport of cholera toxin into the ER of host cells

被引：22
作者：
Lencer, WI
机构：
[1] Childrens Hosp, Harvard Digest Dis Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 293卷 / 7-8期
关键词：
cholera toxin; lipid rafts; membrane transport; endoplasmic reticulum; Golgi;
D O I：
10.1078/1438-4221-00293
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Here we discuss recent studies on the mechanism of transport from plasma membrane to the ER and on the reactions that unfold and retrotranslocate a portion of the toxin to the cytosol where toxicity is induced.
引用
收藏
页码：491 / 494
页数：4
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