Experimental Models of Right Heart Failure: A Window for Translational Research in Pulmonary Hypertension

被引：35

作者：

Guihaire, Julien ^{[1
]}

Bogaard, Harm Jan ^{[2
]}

Flecher, Erwan ^{[3
]}

Noly, Pierre-Emmanuel ^{[1
]}

Mercier, Olaf ^{[1
]}

Haddad, Francois ^{[4
]}

Fadel, Elie ^{[1
]}

机构：

[1] Univ Paris Sud, Marie Lannelongue Hosp, Surg Res Lab, Le Plessis Robinson, France

[2] Vrije Univ Amsterdam Med Ctr, Dept Pulm Med, Amsterdam, Netherlands

[3] Univ Rennes 1, Pontchaillou Hosp, Dept Thorac & Cardiovasc Surg, Rennes, France

[4] Stanford Univ, Div Cardiovasc Med, Palo Alto, CA 94304 USA

来源：

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE | 2013年 / 34卷 / 05期

关键词：

right ventricle; experimental models; pulmonary hypertension; heart failure; pathophysiology; RIGHT-VENTRICULAR HYPERTROPHY; BRAIN NATRIURETIC PEPTIDE; ARTERIAL-HYPERTENSION; PRESSURE-OVERLOAD; PROGNOSTIC VALUE; GENE-EXPRESSION; CHRONIC HYPOXIA; ANIMAL-MODELS; DYSFUNCTION; MONOCROTALINE;

D O I：

10.1055/s-0033-1355444

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The right ventricle (RV) faces major changes in loading conditions associated with cardiovascular and pulmonary vascular disorders. Despite major pharmacological advances since the last decade, pulmonary arterial hypertension remains a deadly disease mainly secondary to the development of right ventricular failure (RVF). Several experimental models of RVF have been developed over the past three decades providing a particular insight in RV pathophysiology. Mechanisms involved in the transition from RV adaptive hypertrophy to maladaptive remodeling and failure in conditions of chronic RV pressure or volume overload are of a great interest but not yet completely understood. Further investigations are needed to find new therapeutic approaches for RVF. Current animal models and emerging concepts of translational RV research will be detailed in this review.

引用

页码：689 / 699

页数：11

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