CANCER An acidic link

被引：7

作者：

Devkota, Suzanne ^{[1
]}

Turnbaugh, Peter J. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA

来源：

NATURE | 2013年 / 499卷 / 7456期

关键词：

GUT MICROBIOME; OBESITY; DIETARY; MICE;

D O I：

10.1038/nature12404

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obese people are at higher risk of multiple types of cancer, but why? One explanation could be that obesity enhances the production of pro-inflammatory, and carcinogenic, bile acids by gut microorganisms. See Letter p.97

引用

页码：37 / 38

页数：2

共 11 条

[1]

Ahmad N. N., 2013, INT J OBES

[2] Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor [J].

Coppe, Jean-Philippe ;

Patil, Christopher K. ;

Rodier, Francis ;

Sun, Yu ;

Munoz, Denise P. ;

Goldstein, Joshua ;

Nelson, Peter S. ;

Desprez, Pierre-Yves ;

Campisi, Judith .

PLOS BIOLOGY, 2008, 6 (12) :2853-2868

[3] Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice [J].

Devkota, Suzanne ;

Wang, Yunwei ;

Musch, Mark W. ;

Leone, Vanessa ;

Fehlner-Peach, Hannah ;

Nadimpalli, Anuradha ;

Antonopoulos, Dionysios A. ;

Jabri, Bana ;

Chang, Eugene B. .

NATURE, 2012, 487 (7405) :104-+

[4] An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice [J].

Fei, Na ;

Zhao, Liping .

ISME JOURNAL, 2013, 7 (04) :880-884

[5] Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease [J].

Greenblum, Sharon ;

Turnbaugh, Peter J. ;

Borenstein, Elhanan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (02) :594-599

[6] Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts [J].

Martens, Eric C. ;

Lowe, Elisabeth C. ;

Chiang, Herbert ;

Pudlo, Nicholas A. ;

Wu, Meng ;

McNulty, Nathan P. ;

Abbott, D. Wade ;

Henrissat, Bernard ;

Gilbert, Harry J. ;

Bolam, David N. ;

Gordon, Jeffrey I. .

PLOS BIOLOGY, 2011, 9 (12)

[7]

Nagengast N. M., 1995, EUR J CANCER, V31, P1067

[8] Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression [J].

Park, Eek Joong ;

Lee, Jun Hee ;

Yu, Guann-Yi ;

He, Guobin ;

Ali, Syed Raza ;

Holzer, Ryan G. ;

Oesterreicher, Christoph H. ;

Takahashi, Hiroyuki ;

Karin, Michael .

CELL, 2010, 140 (02) :197-208

[9] Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist [J].

Sayin, Sama I. ;

Wahlstrom, Annika ;

Felin, Jenny ;

Jantti, Sirkku ;

Marschall, Hanns-Ulrich ;

Bamberg, Krister ;

Angelin, Bo ;

Hyotylainen, Tuulia ;

Oresic, Matej ;

Backhed, Fredrik .

CELL METABOLISM, 2013, 17 (02) :225-235

[10] Systemic gut microbial modulation of bile acid metabolism in host tissue compartments [J].

Swann, Jonathan R. ;

Want, Elizabeth J. ;

Geier, Florian M. ;

Spagou, Konstantina ;

Wilson, Ian D. ;

Sidaway, James E. ;

Nicholson, Jeremy K. ;

Holmes, Elaine .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4523-4530

← 1 2 →