Light-induced liposomes for cancer therapeutics

被引:58
作者
Chen, Wenjie [1 ]
Goldys, Ewa M. [2 ]
Deng, Wei [2 ]
机构
[1] Virginia Commonwealth Univ, Sch Pharm, Dept Pharmaceut, Ctr Pharmaceut Engn & Sci, Richmond, VA 23220 USA
[2] Univ New South Wales, Grad Sch Biomed Engn, ARC Ctr Excellence Nanoscale Biophoton, Kensington, NSW 2052, Australia
基金
英国医学研究理事会;
关键词
Liposomes; Light triggering; Drug/gene delivery; Cancer therapeutics; STIMULI-RESPONSIVE NANOCARRIERS; DRUG-DELIVERY; GOLD NANOPARTICLES; STEALTH LIPOSOMES; TRIGGERABLE LIPOSOMES; THERANOSTIC LIPOSOMES; COMBINATION TREATMENT; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; INDOCYANINE GREEN;
D O I
10.1016/j.plipres.2020.101052
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emerging nanomedicine therapeutics have incorporated photonics technologies to develop precise medical treatment. Among the light regulated approaches, light-induced liposome technology has been explored and developed as a novel tool for spatiotemporal control of cargo release. Compared with the traditional liposome formulation, this triggering feature largely enhanced the therapeutic efficacy and minimized the side effects of the therapeutic substance. In this review paper, we discussed the basics of the light-induced liposomes including the engineering methods and photoresponsiveness mechanisms. We also reviewed current biomedical studies relating to light-induced liposome delivery systems, with an emphasis in the field of cancer therapy.
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收藏
页数:16
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