Spectroscopic and molecular modeling study on the interaction of ctDNA with 3′-deoxy-3′-azido doxorubicin

被引：30

作者：

Geng, Shaoguang ^{[1
]}

Cui, Yanrui ^{[1
]}

Liu, Qingfeng ^{[1
]}

Cui, Fengling ^{[1
]}

Zhang, Guisheng ^{[1
]}

Chi, Yanwei ^{[1
]}

Peng, Hao ^{[2
]}

机构：

[1] Henan Normal Univ, Sch Chem & Chem Engn, Key Lab Green Chem Media & React, Minist Educ, Xinxiang 453007, Peoples R China

[2] Henan Normal Univ, Sch Environm, Xinxiang 453007, Peoples R China

来源：

JOURNAL OF LUMINESCENCE | 2013年 / 141卷

基金：

中国国家自然科学基金;

关键词：

3 '-Deoxy-3 '-azido doxorubicin (ADOX); Calf thymus DNA (ctDNA); Fluorescence spectroscopy; Interaction; Molecular modeling; CALF THYMUS DNA; RESONANCE LIGHT-SCATTERING; COPPER(II) COMPLEX; FLUORESCENCE PROBE; BINDING; DAUNORUBICIN; RESISTANCE; LIGAND; ANALOG;

D O I：

10.1016/j.jlumin.2013.03.034

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The method of synthesizing 3'-deoxy-3'-azido doxorubicin (ADOX) directly from doxorubicin has been developed. This study presents the interaction between ADOX and calf thymus deoxyribonucleic acid (ctDNA) by using spectroscopic methods and molecular modeling techniques. Iodide quenching, fluorescence polarization, viscosity and molecular modeling studies of ADOX-ctDNA interactions indicated that ADOX was an intercalator of ctDNA and preferentially bound to C-G rich regions of ctDNA. Simultaneously, spectroscopic results indicated that the quenching mechanism of ADOX-ctDNA was a static quenching. According to thermodynamic parameters, electrostatic force played roles in the interaction of ADOX with ctDNA. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：144 / 149

页数：6

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