Androgen receptor expression patterns in Becker's nevi: An immunohistochemical study

Background: Becker's nevus (BN) is a hyperpigmented patch that traditionally presents on the upper torso in adolescent males. Previous studies have reported an association with increased androgen receptors (ARs) in lesional skin in men and women who have associated physical abnormalities. Objective: This study was conducted to assess the presence of ARs immunohistochemically in female patients with BN but no other physical abnormalities and compare this finding with BN in males and in normal skin. Methods. Biopsy specimens from Becker's nevi in 3 women and 3 men as well as normal skin in the 3 female subjects were stained with AR antibody, and the level of expression in various cutaneous structures was measured. Results: ARs were increased in dermal fibroblasts in Becker's nevi compared to that found in normal skin. Limitations: The major limitation of the study was the small sample size. Conclusion: In BN there is increased AR expression in dermal fibroblasts; immunohistochemical staining may aid in making the biopsy diagnosis. (J Am Acad Dermatol 2008-59:834-8.)