Low expression of miRNA-224 predicts poor clinical outcome in diffuse large B-cell lymphoma treated with R-CHOP

被引：21

作者：

Ni, Huiyun ^{[1
]}

Wang, Xinfeng ^{[1
]}

Liu, Hong ^{[1
]}

Tian, Fuliang ^{[2
]}

Song, Guoqi ^{[1
]}

机构：

[1] Nantong Univ, Affiliated Hosp, Dept Hematol, Nantong 226001, Jiangsu, Peoples R China

[2] Maternal & Child Hlth Hosp Lianyungang, Liyungang, Jiangsu, Peoples R China

来源：

BIOMARKERS | 2015年 / 20卷 / 04期

关键词：

Biomarkers; diffuse large B-cell lymphoma; microRNA; R-CHOP; CANCER; MICRORNA-224; PROLIFERATION; PROGRESSION; CARCINOMA;

D O I：

10.3109/1354750X.2015.1068855

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To investigate the expression and prognostic value of miR-224 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent R-CHOP. Materials and methods: RT-PCR was used to determine the relative expression of miR-224, in 258 DLBCL patients and 40 normal lymphoid tissue specimens. Results: MiR-224 expression in DLBCL patients was significantly down-regulated compared to that in negative controls (p<0.05). The 5-year progression-free survival and overall survival rates were significantly higher in the high-expression level group compared to the low-expression level group (p<0.05). Conclusions: MiR-224 expression level is implicated as a prognostic marker for DLBCL patients treated with R-CHOP.

引用

页码：253 / 257

页数：5

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