Measuring behavior of animal models: faults and remedies

被引：58

作者：

Fonio, Ehud ^{[1
]}

Golani, Ilan ^{[2
]}

Benjamini, Yoav ^{[3
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[2] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, Sagol Sch Neurosci, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Exact Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel

来源：

NATURE METHODS | 2012年 / 9卷 / 12期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

OPEN-FIELD TEST; FREE EXPLORATION; MOUSE BEHAVIOR; MICE; ANXIETY; EMOTIONALITY; ENVIRONMENT; DISORDERS; GENETICS; STRAINS;

D O I：

10.1038/nmeth.2252

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Widely used behavioral assays need re-evaluation and validation against their intended use. We focus here on measures of chronic anxiety in mouse models and posit that widely used assays such as the open-field test are performed at the wrong time, for inadequate durations and using inappropriate mouse strains. We propose that behavioral assays be screened for usefulness on the basis of their replicability across laboratories.

引用

收藏

页码：1167 / 1170

页数：4

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