The IL-17 Family of Cytokines in Health and Disease

被引：1143

作者：

McGeachy, Mandy J. ^{[1
]}

Cua, Daniel J. ^{[2
]}

Gaffen, Sarah L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Med, Div Rheumatol, Pittsburgh, PA 15260 USA

[2] Merck & Co Inc, Palo Alto, CA 94304 USA

来源：

IMMUNITY | 2019年 / 50卷 / 04期

关键词：

TUMOR-NECROSIS-FACTOR; MESSENGER-RNA STABILITY; DELTA-T-CELLS; KAPPA-B-ZETA; TH17; CELLS; RHEUMATOID-ARTHRITIS; KERATINOCYTE PROLIFERATION; MONOCLONAL-ANTIBODY; SIGNAL-TRANSDUCTION; PSORIATIC-ARTHRITIS;

D O I：

10.1016/j.immuni.2019.03.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25th anniversary of its discovery. Although less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease. Over the past decade, however, it has become clear that the functions of IL-17 are far more nuanced than simply turning on inflammation. Accumulating evidence indicates that IL-17 has important context- and tissue-dependent roles in maintaining health during response to injury, physiological stress, and infection. Here, we discuss the funcions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-7 signal transduction regulation.

引用

页码：892 / 906

页数：15

共 194 条

[71] Differential Roles of Interleukin-17A and-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses [J].

Ishigame, Harumichi ;

Kakuta, Shigeru ;

Nagai, Takeshi ;

Kadoki, Motohiko ;

Nambu, Aya ;

Komiyama, Yutaka ;

Fujikado, Noriyuki ;

Tanahashi, Yuko ;

Akitsu, Aoi ;

Kotaki, Hayato ;

Sudo, Katsuko ;

Nakae, Susumu ;

Sasakawa, Chihiro ;

Iwakura, Yoichiro .

IMMUNITY, 2009, 30 (01) :108-119

[72] A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation [J].

Israel, Laura ;

Bardet, Maureen ;

Huppertz, Antje ;

Mercado, Nicolas ;

Ginster, Stefanie ;

Unterreiner, Adeline ;

Schlierf, Anita ;

Goetschy, Jean Francois ;

Zerwes, Hans-Gunter ;

Roth, Lukas ;

Kolbinger, Frank ;

Bornancin, Frederic .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (09) :2075-2079

[73] Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria [J].

Ivanov, Ivaylo I. ;

Atarashi, Koji ;

Manel, Nicolas ;

Brodie, Eoin L. ;

Shima, Tatsuichiro ;

Karaoz, Ulas ;

Wei, Dongguang ;

Goldfarb, Katherine C. ;

Santee, Clark A. ;

Lynch, Susan V. ;

Tanoue, Takeshi ;

Imaoka, Akemi ;

Itoh, Kikuji ;

Takeda, Kiyoshi ;

Umesaki, Yoshinori ;

Honda, Kenya ;

Littman, Dan R. .

CELL, 2009, 139 (03) :485-498

[74] Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation [J].

Jeltsch, Katharina M. ;

Hu, Desheng ;

Brenner, Sven ;

Zoeller, Jessica ;

Heinz, Gitta A. ;

Nagel, Daniel ;

Vogel, Katharina U. ;

Rehage, Nina ;

Warth, Sebastian C. ;

Edelmann, Stephanie L. ;

Gloury, Renee ;

Martin, Nina ;

Lohs, Claudia ;

Lech, Maciej ;

Stehklein, Jenny E. ;

Geerlof, Arie ;

Kremmer, Elisabeth ;

Weber, Achim ;

Anders, Hans-Joachim ;

Schmitz, Ingo ;

Schmidt-Supprian, Marc ;

Fu, Mingui ;

Holtmann, Helmut ;

Krappmann, Daniel ;

Ruland, Juergen ;

Kallies, Axel ;

Heikenwalder, Mathias ;

Heissmeyer, Vigo .

NATURE IMMUNOLOGY, 2014, 15 (11) :1079-1089

[75] IκBζ is a key driver in the development of psoriasis [J].

Johansen, Claus ;

Mose, Maike ;

Ommen, Pernille ;

Bertelsen, Trine ;

Vinter, Hanne ;

Hailfinger, Stephan ;

Lorscheid, Sebastian ;

Schulze-Osthoff, Klaus ;

Iversen, Lars .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (43) :E5825-E5833

[76] Keratinocyte Overexpression of IL-17C Promotes Psoriasiform Skin Inflammation [J].

Johnston, Andrew ;

Fritz, Yi ;

Dawes, Sean M. ;

Diaconu, Doina ;

Al-Attar, Paul M. ;

Guzman, Andrew M. ;

Chen, Cynthia S. ;

Fu, Wen ;

Gudjonsson, Johann E. ;

McCormick, Thomas S. ;

Ward, Nicole L. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (05) :2252-2262

[77] Is autoimmunity the Achilles' heel of cancer immunotherapy? [J].

June, Carl H. ;

Warshauer, Jeremy T. ;

Bluestone, Jeffrey A. .

NATURE MEDICINE, 2017, 23 (05) :540-+

[78] Post-transcriptional coordination of immunological responses by RNA-binding proteins [J].

Kafasla, Panagiota ;

Skliris, Antonis ;

Kontoyiannis, Dimitris L. .

NATURE IMMUNOLOGY, 2014, 15 (06) :492-502

[79] Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells [J].

Kang, Zizhen ;

Wang, Chenhui ;

Zepp, Jarod ;

Wu, Ling ;

Sun, Kevin ;

Zhao, Junjie ;

Chandrasekharan, Unni ;

DiCorleto, Paul E. ;

Trapp, Bruce D. ;

Ransohoff, Richard M. ;

Li, Xiaoxia .

NATURE NEUROSCIENCE, 2013, 16 (10) :1401-+

[80] Induction of Neutrophil Gelatinase-associated Lipocalin Expression by Co-stimulation with Interleukin-17 and Tumor Necrosis Factor-α Is Controlled by IκB-ζ but neither by C/EBP-β nor C/EBP-δ [J].

Karlsen, Joachim R. ;

Borregaard, Niels ;

Cowland, Jack B. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (19) :14088-14100

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