The IL-17 Family of Cytokines in Health and Disease

被引:1143
作者
McGeachy, Mandy J. [1 ]
Cua, Daniel J. [2 ]
Gaffen, Sarah L. [1 ]
机构
[1] Univ Pittsburgh, Dept Med, Div Rheumatol, Pittsburgh, PA 15260 USA
[2] Merck & Co Inc, Palo Alto, CA 94304 USA
关键词
TUMOR-NECROSIS-FACTOR; MESSENGER-RNA STABILITY; DELTA-T-CELLS; KAPPA-B-ZETA; TH17; CELLS; RHEUMATOID-ARTHRITIS; KERATINOCYTE PROLIFERATION; MONOCLONAL-ANTIBODY; SIGNAL-TRANSDUCTION; PSORIATIC-ARTHRITIS;
D O I
10.1016/j.immuni.2019.03.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25th anniversary of its discovery. Although less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease. Over the past decade, however, it has become clear that the functions of IL-17 are far more nuanced than simply turning on inflammation. Accumulating evidence indicates that IL-17 has important context- and tissue-dependent roles in maintaining health during response to injury, physiological stress, and infection. Here, we discuss the funcions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-7 signal transduction regulation.
引用
收藏
页码:892 / 906
页数:15
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