Development of biodegradable polyesters with various microstructures for highly controlled release of epirubicin and cyclophosphamide

被引：14

作者：

Zoltowska, K. ^{[1
]}

Piotrowska, U. ^{[1
]}

Oledzka, E. ^{[1
]}

Luchowska, U. ^{[1
]}

Sobczak, M. ^{[1
]}

Bocho-Janiszewska, A. ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept BiomatChem, Chair Inorgan & Analyt Chem, Fac Pharm,Lab Med Div, 1 Banacha St, PL-02097 Warsaw, Poland

[2] Kazimierz Pulaski Univ Technol & Humanities, Fac Mat Sci & Design, Dept Inorgan & Phys Chem, Chrobrego 27 St, PL-26600 Radom, Poland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 96卷

关键词：

Biodegradable and bioresorbable biomedical polyesters; Anticancer drug delivery systems; Controlled release; Epirubicin; Cyclophosphamide; RING-OPENING POLYMERIZATION; CONTROLLED DRUG-DELIVERY; BREAST-CANCER; CATALYTIC-SYSTEMS; POLY(LACTIC ACID); POLYMERS; NANOPARTICLES; CARRIERS; THERAPY; LACTIDE;

D O I：

10.1016/j.ejps.2016.10.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, "predominantly isotactic", disyndiotactic, and atactic polylactides (PLAs) and poly(epsilon-caprolactone) s (PCLs) were loaded with anticancer agents, epirubicin (EPI) and cyclophosphamide (CYCLOPHO), to investigate their properties as highly controlled delivery devices. It was found that the kinetic release of drugs from the obtained polyestermatrices tested in vitro at 37 degrees C and pH 7.4 was strongly dependent on average molecular weight (M-n) of the polymers aswell as the PLAs' microstructure. EPI and CYCLOPHO were released from various obtained matrices according to the diffusion, diffusion-degradation, and degradation mechanisms in a rather regular and continuous manner. Importantly, in some cases, the kinetics of the EPI and CYCLOPHO release was nearly zero-order, suggesting predominantly polymer degradation. It is shown that the drug release profiles can be tailored by a controlled design of the microstructure and Mn of polyesters, allowing use of the synthesized matrices for the development of highly controlled biodegradable anticancer drug delivery systems. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：440 / 448

页数：9

共 36 条

[1] Albumin-based micro-composite drug carriers with dual chemo-agents for targeted breast cancer treatment [J].