Ortho-TMS benzaldehyde:: An effective linchpin for type II anion relay chemistry (ARC)

被引：38

作者：

Smith, Amos B., III ^{[1
,2
]}

Kim, Won-Suk ^{[1
,2
]}

Wuest, William M. ^{[1
,2
]}

机构：

[1] Univ Penn, Penn Ctr Mol Discovery, Dept Chem, Philadelphia, PA 19104 USA

[2] Univ Penn, Monell Chem Senses Ctr, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 37期

基金：

美国国家卫生研究院;

关键词：

anion relay chemistry; cross-coupling; dithianes; molecular diversity; natural products;

D O I：

10.1002/anie.200802301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) ARC de triomphe: Ortho-TMS benzaldehyde permits efficient multicomponent union of a variety of nucleophiles and electrophiles, including the first example of a Pd-mediated ARC Type II process. A proof-of-concept" synthetic sequence was designed and implemented for construction of a focused library of "natural product-like" compounds (see scheme). ARC: anion relay chemistry. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：7082 / 7086

页数：5

共 41 条

[1] Rigorous mathematical approaches to strategic bonds and synthetic analysis based on conceptually simple new complexity indices [J].