Developmental origins of brain tumors

被引:38
|
作者
Liu, Chong [1 ]
Zong, Hui [1 ]
机构
[1] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA
关键词
NEURAL STEM-CELLS; MOSAIC ANALYSIS; DOUBLE MARKERS; MEDULLOBLASTOMA; P53; DIFFERENTIATION; CLASSIFICATION; TRANSFORMATION; COMPETENCE; SIGNATURES;
D O I
10.1016/j.conb.2012.04.012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain tumors are devastating owing to the high fatality rate and the devastating impact on life qualities of patients. Recent advancement of comparative transcriptome profiling tools and mouse genetic models has greatly deepened our understanding of the developmental origins of these tumors, which could lead to effective therapeutic strategies. We review recent progresses in three types of brain tumors: ependymoma, medulloblastoma, and malignant glioma. The conceptual framework established by these studies converged on three important aspects. First, subtypes in each tumor group originate from distinct cell types. Second, each cell-of-origin is uniquely susceptible to some but not other genetic mutations. Lastly, mutant stem cells may not transform until they differentiate into more restricted progenitor cell type. Overall, these findings indicate the existence of intricate interactions between gene mutations and developmental program for the formation of brain tumors.
引用
收藏
页码:844 / 849
页数:6
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