Synthesis of 3-aryl-3,4-dihydroquinazolin-2(1H)-ones with the aid of low-valent titanium reagent (TiCl4-Sm)

被引：2

作者：

Shi, Daqing ^{[1
,2
,3
]}

Dou, Guolan ^{[2
]}

Li, Zheng-Yi ^{[2
]}

机构：

[1] Suzhou Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Xuzhou Normal Univ, Coll Chem & Chem Engn, Xuzhou 221116, Peoples R China

[3] Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2007年 / 09期

关键词：

3-aryl-3,4-dihydroquinazolin-2(1H)-one; low-valent titanium reagent; triphosgene; 2-nitrobenzylamine;

D O I：

10.3184/030823407X248306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short and facile synthesis of a series of 3-aryl-3,4-dihydroquinazolin-2(1H)-ones was accomplished in good yields via the novel reductive cyclisation of 2-nitrobenzylamines with bis(trichloromethyl)carbonate (triphosgene) promoted by TiCl4/Sm system. The structures of the products were characterised by IR, H-1 NMR and elemental analysis and the structure of 3a was confirmed by X-ray diffraction analysis.

引用

页码：545 / 547

页数：3

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