Increased mutability to fosfomycin resistance in Proteus mirabilis clinical isolates

被引：7

作者：

Fonseca, Marina R. B. ^{[1
]}

Sato, Juliana L. ^{[1
]}

Lima-Noronha, Marco A. ^{[1
]}

Migliorini, Leticia B. ^{[1
]}

Fernandez-Silva, Frank S. ^{[1
]}

Galhardo, Rodrigo S. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, SP, Brazil

来源：

INFECTION GENETICS AND EVOLUTION | 2018年 / 58卷

基金：

巴西圣保罗研究基金会;

关键词：

Mutators; Mutagenesis; Fosfomycin resistance; Proteus mirabilis; ELEMENTS CARRYING BLA(CMY-2); URINARY-TRACT-INFECTION; ESCHERICHIA-COLI; MUTATION FREQUENCIES; BETA-LACTAMASE; EMERGENCE; SUSCEPTIBILITY; PREVALENCE; MECHANISMS; MUTATORS;

D O I：

10.1016/j.meegid.2017.12.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In the present study, we screened a collection of 77 Proteus mirabilis clinical isolates for the presence of mutators, using the frequency of both rifampicin and fosfomycin resistance mutants as markers of spontaneous mutagenesis. We found that none of the strains in our collection are mutators for the rifampicin resistance (Rif(R)) marker. Nevertheless, a significant fraction of the isolates (17%) show high frequencies of fosfomycin resistant mutants (Fos(R)). We show that this increased mutability to FosR correlates with a low level of resistance to Fosfomycin (MICs 8-64 mu g/ml). These strains also show high frequencies of single step mutants with clinically relevant FosR resistance levels (MIC >= 256 mu g/ml). Our findings point out to the risk of fosfomycin resistance emergence in P. mirabilis.

引用

页码：27 / 33

页数：7

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