USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail

被引：40
作者：
Li, Lei [1 ,2 ]
Zhou, Honghong [1 ,2 ,3 ]
Zhu, Rui [1 ,2 ]
Liu, Zhihua [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Natl Clin Res Ctr Canc, Canc Hosp, State Key Lab Mol Oncol,Natl Canc Ctr, Beijing 100021, Peoples R China
[2] Peking Union Med Coll, Beijing 100021, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, Ctr Big Data Res Hlth, Key Lab RNA Biol, Beijing 100101, Peoples R China
来源：
CANCER LETTERS | 2019年 / 448卷
基金：
美国国家科学基金会; 国家重点研发计划;
关键词：
USP26; Snail; Deubiquitination; Epithelial-mesenchymal transition; ESCC; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-METASTASIS; PHOSPHORYLATION; DEGRADATION; MECHANISMS; EXPRESSION; PATHWAY; EMT; P53;
D O I：
10.1016/j.canlet.2019.02.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Snail is an important transcription factor of epithelial-mesenchymal transition (EMT) and related to poor prognosis and distant metastasis of tumor patients. Snail is a liable protein and degraded by ubiquitin-proteasome system. There are various E3 ligases mediating its degradation, but the deubiquitinating enzyme reversed Snail degradation is not fully understood. In this study, we screened a DUB library and found USP26 is a potent deubiquitinase mediating Snail stabilization. We also identified that USP26 is a booster of esophageal squamous cell carcinoma (ESCC) cell migration and invasion, and it is highly expressed in ESCC samples. Our observation demonstrates that USP26 is a novel deubiquitinating enzyme of Snail and it provides a potential target for the therapy of esophageal cancer metastasis.
引用
收藏
页码：52 / 60
页数：9
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