USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail

被引：42

作者：

Li, Lei ^{[1
,2
]}

Zhou, Honghong ^{[1
,2
,3
]}

Zhu, Rui ^{[1
,2
]}

Liu, Zhihua ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Natl Clin Res Ctr Canc, Canc Hosp, State Key Lab Mol Oncol,Natl Canc Ctr, Beijing 100021, Peoples R China

[2] Peking Union Med Coll, Beijing 100021, Peoples R China

[3] Chinese Acad Sci, Inst Biophys, Ctr Big Data Res Hlth, Key Lab RNA Biol, Beijing 100101, Peoples R China

来源：

CANCER LETTERS | 2019年 / 448卷

基金：

美国国家科学基金会; 国家重点研发计划;

关键词：

USP26; Snail; Deubiquitination; Epithelial-mesenchymal transition; ESCC; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-METASTASIS; PHOSPHORYLATION; DEGRADATION; MECHANISMS; EXPRESSION; PATHWAY; EMT; P53;

D O I：

10.1016/j.canlet.2019.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Snail is an important transcription factor of epithelial-mesenchymal transition (EMT) and related to poor prognosis and distant metastasis of tumor patients. Snail is a liable protein and degraded by ubiquitin-proteasome system. There are various E3 ligases mediating its degradation, but the deubiquitinating enzyme reversed Snail degradation is not fully understood. In this study, we screened a DUB library and found USP26 is a potent deubiquitinase mediating Snail stabilization. We also identified that USP26 is a booster of esophageal squamous cell carcinoma (ESCC) cell migration and invasion, and it is highly expressed in ESCC samples. Our observation demonstrates that USP26 is a novel deubiquitinating enzyme of Snail and it provides a potential target for the therapy of esophageal cancer metastasis.

引用

页码：52 / 60

页数：9

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