A model of phototransduction by the human circadian system

被引：279
作者：
Rea, MS [1 ]
Figueiro, MG [1 ]
Bullough, JD [1 ]
Bierman, A [1 ]
机构：
[1] Rensselaer Polytech Inst, Lighting Res Ctr, Troy, NY 12180 USA
来源：
BRAIN RESEARCH REVIEWS | 2005年 / 50卷 / 02期
关键词：
melatonin suppression; melanopsin; spectral sensitivity; retinal ganglion cell; spectral opponency; retina; photoreceptor; circadian rhythm;
D O I：
10.1016/j.brainresrev.2005.07.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The absolute and spectral sensitivities to light by the human cireadian system, measured through melatonin Suppression or phase shifting response, are beginning to emerge after a quarter century of active research. The present paper Outlines a hypothesized model of human circadian phototransduction that is consistent with the known neuroanatomy and physiology of the human Visual and circadian systems. Spectral opponency is fundamental to file model, providing a parsimonious explanation of some recently published data. The proposed model offers a framework for hypothesis testing and subsequent discussion Of file practical aspects of architectural lighting with respect to light and health. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：213 / 228
页数：16
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