Beyond ribosomal DNA: On towards the telomere

被引：11

作者：

Gonzalez, IL ^{[1
]}

Sylvester, JE ^{[1
]}

机构：

[1] ALLEGHENY UNIV HLTH SCI,MED COLL PENN HAHNEMANN SCH MED,DEPT PATHOL,BROAD & VINE,PHILADELPHIA,PA 19102

来源：

CHROMOSOMA | 1997年 / 105卷 / 7-8期

关键词：

D O I：

10.1007/s004120050204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have sequenced and analyzed 8.3 kb of sequence adjacent and distal to the human ribosomal DNA (rDNA); this distal sequence connects to the rDNA cluster just 4 kb upstream of the first promoter and is shared among the acrocentric chromosomes and, at least in part, it is also present in other primates. The sequence differs in character from that of the rDNA intergenic spacer (IGS) in that it does not contain long stretches of either polypyrimidine or polypurine. However, just like the IGS, it contains numerous repetitive elements, including retroposed fragments of 28S rRNA and large pieces of the IGS. In addition, we show that the rDNA clusters are not interrupted by other sequences and do not recombine with this distal segment.

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页码：431 / 437

页数：7

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