Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores

被引:36
作者
Bae, CJ
Kim, HW
Koh, YH
Kim, HE [1 ]
机构
[1] Seoul Natl Univ, Sch Mat Sci & Engn, Seoul 151742, South Korea
[2] Dankook Univ, Sch Dent, Dept Dent Biomat, Cheonan 330714, South Korea
关键词
D O I
10.1007/s10856-006-8934-2
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of similar to 450 mu m, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.
引用
收藏
页码:517 / 521
页数:5
相关论文
共 23 条
[1]   EVALUATION OF A BIODEGRADABLE CERAMIC [J].
CAMERON, HU ;
MACNAB, I ;
PILLIAR, RM .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1977, 11 (02) :179-186
[2]   Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures [J].
Chu, TMG ;
Orton, DG ;
Hollister, SJ ;
Feinberg, SE ;
Halloran, JW .
BIOMATERIALS, 2002, 23 (05) :1283-1293
[3]   Hydroxyapatite implants with designed internal architecture [J].
Chu, TMG ;
Halloran, JW ;
Hollister, SJ ;
Feinberg, SE .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2001, 12 (06) :471-478
[4]   GRANULATES BASED ON CALCIUM-PHOSPHATE WITH CONTROLLED MORPHOLOGY AND POROSITY FOR MEDICAL APPLICATIONS - PHYSICOCHEMICAL PARAMETERS AND PRODUCTION TECHNIQUE [J].
FABBRI, M ;
CELOTTI, GC ;
RAVAGLIOLI, A .
BIOMATERIALS, 1994, 15 (06) :474-477
[5]   BIOCERAMICS - FROM CONCEPT TO CLINIC [J].
HENCH, LL .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 1991, 74 (07) :1487-1510
[6]  
JARCHO M, 1981, CLIN ORTHOP RELAT R, P259
[7]   Dissolution control and cellular responses of calcium phosphate coatings on zirconia porous scaffold [J].
Kim, HW ;
Kim, HE ;
Salih, V ;
Knowles, JC .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 68A (03) :522-530
[8]   Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer [J].
Kim, HW ;
Lee, SY ;
Bae, CJ ;
Noh, YJ ;
Kim, HE ;
Kim, HM ;
Ko, JS .
BIOMATERIALS, 2003, 24 (19) :3277-3284
[9]   Macrochanneled tetragonal zirconia polycrystals coated by a calcium phosphate layer [J].
Koh, YH ;
Kim, HW ;
Kim, HE ;
Halloran, JW .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2003, 86 (12) :2027-2030
[10]   Fabrication of macrochannelled-hydroxyapatite bioceramic by a coextrusion process [J].
Koh, YH ;
Kim, HW ;
Kim, HE ;
Halloran, JW .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2002, 85 (10) :2578-2580