Effects of Apolipoprotein E Polymorphism on Cerebral Oxygen Saturation After Traumatic Brain Injury

Objective: To investigate the effects of the apolipoprotein E gene (APOE) on the cerebral oxygen saturation of patients after traumatic brain injury (TBI). Methods: Clinical data of 114 patients with TBI and 54 normal people were collected. The APOE genotypes of all subjects were determined by quantitative fluorescent polymerase chain reaction (QF-PCR). The regional cerebral oxygen saturation (rScO(2)) of TBI patients and normal people were monitored by near-infrared spectroscopy (NIRS). Results: The mean rScO(2) of patients was (55.06 +/- 7.60)% in the early stage of TBI, which was significantly lower than that of normal people (67.21 +/- 7.80)% (P < 0.05). Single-factor and multifactor logistic regression analyses showed APOE epsilon 4 was an independent risk factor that caused the early decline of rScO2 in TBI patients. Furthermore, in the TBI group, the rScO(2) of APOE epsilon 4 carriers (52.23 +/- 8.02)% was significantly lower than that of non-epsilon 4 carriers (60.33 +/- 7.12)% (P < 0.05). But in the normal group, no significant differences in rScO(2) were found between APOE epsilon 4 carriers and non-carriers. Conclusion: The rScO(2) may be significantly decreased after TBI, and APOE epsilon 4 may be a risk factor for decreased rScO(2) in the early stage of TBI.