Since the reform and opening up, the rapid development of science and technology make every industry has a big opportunity for development, clothing business is the same. Especially since China's accession to WTO, China's garment enterprises have been refined and improved in all aspects. However, in the development of garment enterprises, they are facing more intense competition in the market, and compared to other countries. China's garment industry is currently widespread reduction in product life, high operating costs and management behind such problems, thereby resulting in China's garment production enterprises in the international competitiveness decreased significantly. ERP system as an advanced management mode, and its application in the domestic apparel production enterprises to achieve the greatest degree of management of garment manufacturers, to improve the utilization of funds and reduce operational risks has an indispensable role. Thus, the paper studies the current status of the domestic garment manufacturers in the ERP system, and application problems were studied in detail, and then discusses the design and implementation of the garment manufacturing enterprises ERP system.