A structural analysis of the natural egress of Toxoplasma gondii

被引：11
|
作者：
Caldas, Lucio Ayres [1 ]
Attias, Marcia [1 ]
de Souza, Wanderley [1 ,2 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil
[2] Inst Nacl Ciencia & Tecnol Biol Estrut & Bioimage, Rio De Janeiro, Brazil
来源：
MICROBES AND INFECTION | 2018年 / 20卷 / 01期
关键词：
Parasite interactions; Egress; Toxoplasma microscopy; HOST-CELL INVASION; CALCIUM IONOPHORE; CONOID EXTRUSION; TACHYZOITES; POTASSIUM; KINASE; ACTIN; EXIT;
D O I：
10.1016/j.micinf.2017.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Previous studies have analysed the process of Toxoplasma gondii egress with the aid of inducers, such as calcium ionophores. Although calcium transients have been successful in triggering T. gondii egress, the structural panorama of "natural" and artificial events should match. The present study approaches the natural egress of this parasite using super-resolution and electron microscopy and reveals lytic and non-lytic events of individual egress; this corroborates the use of calcium ionophore as a reliable tool to trigger parasite egress. Altogether, our data suggest that different signalling routes can converge to similar structural aspects in natural and induced egress. (C) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：57 / 62
页数：6
相关论文
共 50 条
  • [31] Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress
    Gaji, Rajshekhar Y.
    Johnson, Derrick E.
    Treeck, Moritz
    Wang, Mu
    Hudmon, Andy
    Arrizabalaga, Gustavo
    PLOS PATHOGENS, 2015, 11 (11)
  • [32] Effects of Estradiol and Progesterone-Induced Intracellular Calcium Fluxes on Toxoplasma gondii Gliding, Microneme Secretion, and Egress
    Zhang, Xiao
    Zhang, Heng
    Fu, Yong
    Liu, Jing
    Liu, Qun
    FRONTIERS IN MICROBIOLOGY, 2018, 9
  • [33] The life-cycle of Toxoplasma gondii reviewed using animations
    Attias, Marcia
    Teixeira, Dirceu E.
    Benchimol, Marlene
    Vommaro, Rossiane C.
    Crepaldi, Paulo Henrique
    De Souza, Wanderley
    PARASITES & VECTORS, 2020, 13 (01)
  • [34] A druggable secretory protein maturase of Toxoplasma essential for invasion and egress
    Dogga, Sunil Kumar
    Mukherjee, Budhaditya
    Jacot, Damien
    Kockmann, Tobias
    Molino, Luca
    Hammoudi, Pierre-Mehdi
    Hartkoorn, Ruben C.
    Hehl, Adrian B.
    Soldati-Favre, Dominique
    ELIFE, 2017, 6
  • [35] Dynamics and 3D organization of secretory organelles of Toxoplasma gondii
    Paredes-Santos, Tatiana Christina
    de Souza, Wanderley
    Attias, Marcia
    JOURNAL OF STRUCTURAL BIOLOGY, 2012, 177 (02) : 420 - 430
  • [36] Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress
    Dubois, David J.
    Chehade, Sylia
    Jean-Baptiste, Marq
    Venugopal, Kannan
    Maco, Bohumil
    Puig, Albert Tell I.
    Soldati-Favre, Dominique
    Marion, Sabrina
    MBIO, 2023, 14 (03): : 1 - 19
  • [37] Global research landscape and trends in Toxoplasma gondii from 2003 to 2022: A bibliometric analysis
    Fan, Shi-Jie
    Pan, Ming
    Xia, Chen-Yang
    Yang, Pin
    Huang, Si-Yang
    VETERINARY PARASITOLOGY, 2025, 335
  • [38] Virulence factors of Toxoplasma gondii
    Dubremetz, Jean Francois
    Lebrun, Maryse
    MICROBES AND INFECTION, 2012, 14 (15) : 1403 - 1410
  • [39] Toxoplasma gondii: Proteomic analysis of antigenicity of soluble tachyzoite antigen
    Ma, Guang-Yuan
    Zhang, Jian-Zhong
    Yin, Guo-Rong
    Zhang, Jian-Hong
    Meng, Xiao-Li
    Zhao, Fei
    EXPERIMENTAL PARASITOLOGY, 2009, 122 (01) : 41 - 46
  • [40] Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex
    Pacheco, Nicolas Dos Santos
    Tosetti, Nicolo
    Krishnan, Aarti
    Haase, Romuald
    Maco, Bohumil
    Suarez, Catherine
    Ren, Bingjian
    Soldati-Favre, Dominique
    MBIO, 2021, 12 (05):
12345