A structural analysis of the natural egress of Toxoplasma gondii

被引：12
作者：
Caldas, Lucio Ayres [1 ]
Attias, Marcia [1 ]
de Souza, Wanderley [1 ,2 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil
[2] Inst Nacl Ciencia & Tecnol Biol Estrut & Bioimage, Rio De Janeiro, Brazil
来源：
MICROBES AND INFECTION | 2018年 / 20卷 / 01期
关键词：
Parasite interactions; Egress; Toxoplasma microscopy; HOST-CELL INVASION; CALCIUM IONOPHORE; CONOID EXTRUSION; TACHYZOITES; POTASSIUM; KINASE; ACTIN; EXIT;
D O I：
10.1016/j.micinf.2017.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Previous studies have analysed the process of Toxoplasma gondii egress with the aid of inducers, such as calcium ionophores. Although calcium transients have been successful in triggering T. gondii egress, the structural panorama of "natural" and artificial events should match. The present study approaches the natural egress of this parasite using super-resolution and electron microscopy and reveals lytic and non-lytic events of individual egress; this corroborates the use of calcium ionophore as a reliable tool to trigger parasite egress. Altogether, our data suggest that different signalling routes can converge to similar structural aspects in natural and induced egress. (C) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：57 / 62
页数：6
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