Molecular Mechanism ofHelicobacter pylori-Induced Gastric Cancer

Introduction Various types of cancers threaten human life. The role of bacteria in causing cancer is controversial, but it has been determined that theHelicobacter pyloriinfection is one of the identified risk factors for gastric cancer.Helicobacter pyloriinfection is highly prevalent, and about half of the world(,)s population is infected with it. Objective The aim of this study was the role ofHelicobacter pyloriin the development of gastric cancer. Method We obtained information from previously published articles. Results and Conclusion The bacterium has various virulence factors, including cytotoxin- associated gene A, vacuolating cytotoxin A, and the different outer membrane proteins that cause cancer by different mechanisms. These virulence factors activate cell signaling pathways such as PI3-kinase/Akt, JAK/STAT and Ras, Raf, and ERK signaling that control cell proliferation. Uncontrolled proliferation can lead to cancer.