Intratumoral alterations of dendritic-cell differentiation and CD8+ T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma

被引：58
|
作者：
Noessner, Elfriede [1 ]
Brech, Dorothee [1 ]
Mendler, Anna N. [1 ]
Masouris, Ilias [1 ]
Schlenker, Ramona [1 ]
Prinz, Petra U. [1 ]
机构：
[1] Helmholtz Ctr Munich, German Res Ctr Environm Hlth, Inst Mol Immunol, Munich, Germany
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 08期
关键词：
dendritic cells; immune escape; renal cell carcinoma; tumor-infiltrating lymphocytes; tumor milieu;
D O I：
10.4161/onci.21356
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytotoxic lymphocytes and dendritic cells infiltrating human renal cell carcinoma (RCC) are not sufficient to prevent tumor progression. Our studies identified alterations of the immune cell infiltrate as well as some of the underlying mechanisms. This knowledge should facilitate the development of anti-RCC therapies that achieve better tumor control.
引用
收藏
页码：1451 / 1453
页数：3
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