Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets: a case study of gloss, surface roughness and bulk properties of starch acetate tablets

被引：37

作者：

Juuti, M. ^{[1
]}

Tuononen, H. ^{[2
]}

Prykari, T. ^{[3
]}

Kontturi, V. ^{[2
]}

Kuosmanen, M. ^{[4
]}

Alarousu, E. ^{[3
]}

Ketolainen, J. ^{[4
]}

Myllyla, R. ^{[3
]}

Peiponen, K-E ^{[2
]}

机构：

[1] VTT Tech Res Ctr Finland, FI-70211 Kuopio, Finland

[2] Univ Joensuu, Dept Math & Phys, FI-80101 Joensuu, Finland

[3] Univ Oulu, Optoelect & Measurement Tech Lab, FI-90014 Oulu, Finland

[4] Univ Kuopio, Dept Pharmaceut, FI-70211 Kuopio, Finland

来源：

MEASUREMENT SCIENCE AND TECHNOLOGY | 2009年 / 20卷 / 01期

基金：

芬兰科学院;

关键词：

tablet; surface quality; roughness; porosity; terahertz spectroscopy; optical coherence tomography; gloss measurement; PULSED SPECTROSCOPY; COMPACTS;

D O I：

10.1088/0957-0233/20/1/015301

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Surface and bulk properties of flat-faced starch acetate tablets were studied. For surface quality inspection optical coherence tomography and recently developed diffractive glossmeter were utilized. Both these optical devices together provide local information on surface roughness and gloss of a tablet over a measured area. The concepts of mean topography and mean gloss profile for surface quality of a tablet are introduced. It was observed that the surface quality of the tablet varies, and compression at high pressure may not guarantee a good surface quality of the tablet. Using novel statistical parameters for gloss and relevant surface roughness parameter, it is possible to get more comprehensive quantitative data on the surface condition of a tablet. THz spectrometer was utilized for detection of THz pulse delay in transmission measurement mode from the tablets. The delay time and thickness ratio of the tablet are consistent with the porosity of the tablet as a function of compression pressure. We suggest that the multimeasurement scheme using three different devices helps tablet makers to better assess bulk and surface quality of their products.

引用

页数：9

共 27 条

[1] Study on the use of optical coherence tomography in measurements of paper properties [J].