Glutathione S-transferase T1 genetic mismatch is a risk factor for de novo immune hepatitis in liver transplantation

被引：22

作者：

Aguilera, I

Sousa, JM

Gavilan, F

Bernardos, A

Wichmann, I

Nuñez-Roldan, A

机构：

[1] Univ Seville, Hosp Virgen del Rocio, Serv Inmunol, Seville, Spain

[2] Univ Seville, Hosp Virgen del Rocio, Unidad Transplante Hepat, Seville, Spain

[3] Univ Seville, Hosp Virgen del Rocio, Serv Anat Patol, Seville, Spain

来源：

TRANSPLANTATION PROCEEDINGS | 2005年 / 37卷 / 09期

关键词：

D O I：

10.1016/j.transproceed.2005.10.042

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glutathione S-transferase T1 (GSTT1) is a drug metabolizing enzyme abundantly expressed in liver and kidney cells; it is encoded by a single gene that is absent in 20% of the Caucasian population. Our group found that some liver transplantation patients developed de novo immune hepatitis (IH) and that all of them had anti-GSTT1 antibodies. The main objective of this study was to analyze the influence of a GSTT1 mismatch between donor and recipient in the immune response and the outcome of the graft. We confirmed that only under one of the four possible genetic combinations (null recipient/positive donor) is an alloimmune response triggered with production of anti-GSTT1 antibodies. Therefore, we conclude that this genetic mismatch can be considered a risk factor for de novo IH.

引用

页码：3968 / 3969

页数：2

共 6 条

[1] Antibodies against glutathione S-transferase T1 (GSTT1) in patients with de novo immune hepatitis following liver transplantation [J].