Thiol derivatization of Xanthan gum and its evaluation as a mucoadhesive polymer

被引：61
作者：
Bhatia, Meenakshi [1 ]
Ahuja, Munish [1 ]
Mehta, Heena [1 ]
机构：
[1] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Drug Delivery Res Lab, Hisar 125001, Haryana, India
来源：
CARBOHYDRATE POLYMERS | 2015年 / 131卷
关键词：
Xanthan gum; Thiolation; Mucoadhesion; Buccal pellets; DICLOFENAC SODIUM; RELEASE; FORMULATION; MUCILAGE;
D O I：
10.1016/j.carbpol.2015.05.049
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Thiol-derivatization of xanthan gum polysaccharide was carried out by esterification with mercaptopropionic acid and thioglycolic acid. Thiol-derivatization was confirmed by Fourier-transformed infra-red spectroscopy. Xanthan-mercaptopropionic acid conjugate and xanthan-thioglycolic acid conjugate were found to possess 432.68 mM and 465.02 mM of thiol groups as determined by Ellman's method respectively. Comparative evaluation of mucoadhesive property of metronidazole loaded buccal pellets of xanthan and thiolated xanthan gum using chicken buccal pouch membrane revealed higher ex vivo bioadhesion time of thiolated xanthan gum as compared to xanthan gum. Improved mucoadhesive property of thiolated xanthan gum over the xanthan gum can be attributed to the formation of disulfide bond between mucus and thiolated xanthan gum. In vitro release study conducted using phosphate buffer (pH 6.8) revealed a sustained release profile of metronidazole from thiolated xanthan pellets as compared to xanthan pellets. In conclusion, thiolation of xanthan improves its mucoadhesive property and sustained the release of metronidazole over a prolonged period. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：119 / 124
页数：6
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