Higher Levels of Hair Ethyl Glucuronide in Patients with Decreased Kidney Function

被引：29

作者：

Hoiseth, Gudrun ^{[1
,2
]}

Morini, Luca ^{[3
]}

Ganss, Rudiger ^{[4
]}

Nordal, Kristin ^{[1
]}

Morland, Jorg ^{[1
]}

机构：

[1] Norwegian Inst Publ Hlth, Div Forens Med & Drug Abuse Res, N-0403 Oslo, Norway

[2] Diakonhjemmet Hosp, Ctr Psychopharmacol, Oslo, Norway

[3] Univ Pavia, Dept Legal Med & Publ Hlth Forens & Pharmacotoxic, I-27100 Pavia, Italy

[4] Akershus Univ Hosp, Div Internal Med, Dept Nephrol, Lorenskog, Norway

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2013年 / 37卷

关键词：

Alcohol; Biomarker; Ethyl Glucuronide; SAMPLES;

D O I：

10.1111/j.1530-0277.2012.01882.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Background Hair levels of ethyl glucuronide (EtG) are often used to differentiate social drinking from heavy drinking. Patients with decreased kidney function have delayed excretion of EtG, and increased incorporation into hair could be suspected. The aim of this study was to compare hair EtG levels in patients with decreased kidney function to those seen in healthy volunteers. Methods Twelve patients with renal disease were included. The levels of EtG in hair were adjusted to estimated daily intake of ethanol (EDI) and compared to 21 previously published healthy individuals. Results The levels of hair EtG in the 12 patients ranged between < limit of detection and 134 pg/mg, and the EDI ranged between 0.1 and 12 g. The levels of EtG in hair were significantly higher in the patients compared to healthy volunteers (p = 0.009). Conclusions These preliminary results indicate that hair levels of EtG in a population of patients with decreased kidney function should be interpreted with caution.

引用

页码：E14 / E16

页数：3

共 16 条

[1] Determination of ethyl glucuronide in hair samples [J].