CD11c regulates late-stage T cell development in the thymus

被引：5
作者：
Hou, Lifei [1 ,2 ]
Yuki, Koichi [1 ,2 ]
机构：
[1] Boston Childrens Hosp, Cardiac Anesthesia Div, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Anaesthesia & Immunol, Boston, MA 02115 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
CD11c; thymus; dendritic cell; apoptosis; T cell development; NEGATIVE SELECTION; DENDRITIC CELLS; ALPHA-SUBUNIT; THYMOCYTES; MIGRATION; TOLERANCE; MEDULLA; GENES;
D O I：
10.3389/fimmu.2022.1040818
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD11c, also named integrin alpha X, has been deemed solely as a dendritic cell marker for decades while the delineation of its biological function was limited. In the current study, we observed in mice that CD11c deficiency led to a defect in T cell development, demonstrated by the loss of CD4(+)CD8(+) double positive (DP) T cells, CD4(+)CD8(-), and CD4(-)CD8(+) single positive (SP) T cells in the thymus and less mature T cells in the periphery. By using bone marrow chimera, we confirmed that CD11c regulated T cell development in the thymus. We further showed that CD11c deficiency led to an accelerated apoptosis of CD3 positive thymocytes, but not CD4(-)CD8(-) double negative (DN) T cells. Overall, this study added one more layer of knowledge on the regulatory mechanism of late-stage T cell development that the presence of CD11c in the thymus is critical for maintaining T cell survival.
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页数：8
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