Measuring conduction velocity distributions in peripheral nerves using neurophysiological techniques

被引:7
作者
Ni, Zhen [1 ]
Vial, Felipe [1 ,2 ]
Avram, Alexandru, V [3 ]
Leodori, Giorgio [4 ]
Pajevic, Sinisa [5 ]
Basser, Peter J. [6 ]
Hallett, Mark [1 ]
机构
[1] NINDS, Human Motor Control Sect, NIH, Bldg 10,Room 7D37,10 Ctr Dr,MSC 1428, Bethesda, MD 20892 USA
[2] Alemana Univ Desarrollo, Fac Med Clin, Santiago, Chile
[3] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD USA
[4] IRCCS Neuromed, Pozzilli, Italy
[5] NIH, Math & Stat Comp Lab, Ctr Informat Technol, Bldg 10, Bethesda, MD 20892 USA
[6] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Quantitat Imaging & Tissue Sci, NIH, Bethesda, MD USA
关键词
Collision; Compound muscle action potential; Compound nerve action potential; Conduction velocity; Motor nerve and mixed nerve; Peripheral electrical nerve stimulation; SINGLE-FIBER; MOTOR UNITS; TEMPORAL DISPERSION; REFRACTORY PERIOD; SURAL NERVE; DIFFUSION; DIAMETER; AXONS; MRI; CONNECTOME;
D O I
10.1016/j.clinph.2020.04.008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To determine how long it takes for neural impulses to travel along peripheral nerve fibers in living humans. Methods: A collision test was performed to measure the conduction velocity distribution of the ulnar nerve. Two stimuli at the distal and proximal sites were used to produce the collision. Compound muscle or nerve action potentials were recorded to perform the measurements on the motor or mixed nerve, respectively. Interstimulus interval was set at 1-5 ms. A quadri-pulse technique was used to measure the refractory period and calibrate the conduction time. Results: Compound muscle action potential produced by the proximal stimulation started to emerge at the interstimulus interval of about 1.5 ms and increased with the increment in interstimulus interval. Two groups of motor nerve fibers with different conduction velocities were identified. The mixed nerve showed a wider conduction velocity distribution with identification of more subgroups of nerve fibers than the motor nerve. Conclusions: The conduction velocity distributions in high resolution on a peripheral motor and mixed nerve are different and this can be measured with the collision test. Significance: We provided ground truth data to verify the neuroimaging pipelines for the measurements of latency connectome in the peripheral nervous system. Published by Elsevier B.V. on behalf of International Federation of Clinical Neurophysiology.
引用
收藏
页码:1581 / 1588
页数:8
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