Synthesis of 10-(R-benzoyl)-2,4-dimethyl-6-(R-phenyl)-8,9-dihydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-1,3(2H,4H)-diones and 2,4-dimethyl-9,10-dihydro-6λ4-pyrimido[5,4-d]pyrrolo- [1,2-b][1,2,6]thiadiazine-1,3,6(2H,4H,8H)-trione

被引：0

作者：

Gasparyan, S. P. ^{[1
]}

Alexanyan, M. V. ^{[1
]}

Harutyunyan, G. K. ^{[1
]}

Martirosyan, A. H. ^{[1
]}

Stepanyan, H. M. ^{[1
]}

Muradyan, R. E. ^{[1
]}

Tamazyan, R. A. ^{[2
]}

Ayvazyan, A. G. ^{[2
]}

机构：

[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Mndzhoyan Inst Fine Organ Chem, Pr Azatutyan 26, Yerevan 0014, Armenia

[2] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Mol Struct Res Ctr, Pr Azatutyan 26, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 52卷 / 09期

关键词：

INHIBITION;

D O I：

10.1134/S1070428016090177

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Imino-1,3-dimethyl-5-(pyrrolidin-2-ylidene)-5,6-dihydropyrimidine-2,4(1H,3H)-dione reacted with substituted benzoyl chlorides in the presence of triethylamine to give the corresponding 10-(R-benzoyl)-2,4-dimethyl-6-(R-phenyl)-8,9-dihydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-1,3(2H,4H)-diones. Analogous reaction with thionyl chloride afforded 2,4-dimethyl-9,10-dihydro-6 lambda(4)-pyrimido[5,4-d]pyrrolo[1,2-b][1,2,6]-thiadiazine-1,3,6(2H,4H,8H)-trione.

引用

页码：1348 / 1352

页数：5

共 12 条

[1]

BERNIER JL, 1980, J PHARM SCI-US, V69, P1343, DOI 10.1002/jps.2600691128

[2] INHIBITION OF FERROUS-INDUCED LIPID-PEROXIDATION BY PYRIMIDO-PYRIMIDINE DERIVATIVES IN HUMAN LIVER MEMBRANES [J].