Concurrent video-rate color and near-infrared fluorescence laparoscopy

被引：49

作者：

Glatz, Juergen ^{[1
]}

Varga, Julia ^{[2
]}

Garcia-Allende, Pilar Beatriz ^{[3
]}

Koch, Maximilian ^{[3
]}

Greten, Florian R. ^{[2
]}

Ntziachristos, Vasilis ^{[1
,3
]}

机构：

[1] Tech Univ Munich, Chair Biol Imaging, D-80290 Munich, Germany

[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-80290 Munich, Germany

[3] Helmholtz Zentrum Munchen, Inst Biol & Med Imaging, Oberschleissheim, Germany

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2013年 / 18卷 / 10期

关键词：

cancer; laparoscopy; endoscopy; near-infrared imaging; optical imaging; intraoperative imaging; fluorescence imaging; MOUSE MODELS; CANCER; COLONOSCOPY; INFLAMMATION; TUMORS; DIAGNOSIS; ONCOLOGY; POLYP; GENE; MICE;

D O I：

10.1117/1.JBO.18.10.101302

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The visual identification and demarcation of tumors and tumor margins remains challenging due to the low optical contrast of cancer cells over surrounding tissues. Fluorescence molecular imaging was recently considered clinically for improving cancer detection during open surgery. We present herein a next step in the development of fluorescence molecular guidance by describing a novel video-rate imaging laparoscope capable of concurrently recording color and near-infrared fluorescence images and video. Video-rate operation is based on graphics processing unit-based image processing. We examine the optical characteristics of the system developed and provide performance metrics related to intra-operative endoscopic guidance, showcased on phantoms and endoscopic color and fluorescence molecular imaging of tumors in a mouse model of the human disease. c 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：7

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