Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy Combined with Radiotherapy and Sorafenib for Advanced Hepatocellular Carcinoma Patients with Major Portal Vein Tumor Thrombosis

被引：40

作者：

Kodama, Kenichiro ^{[1
]}

Kawaoka, Tomokazu ^{[1
]}

Aikata, Hiroshi ^{[1
]}

Uchikawa, Shinsuke ^{[1
]}

Nishida, Yuno ^{[1
]}

Inagaki, Yuki ^{[1
]}

Hatooka, Masahiro ^{[1
]}

Morio, Kei ^{[1
]}

Nakahara, Takashi ^{[1
]}

Murakami, Eisuke ^{[1
]}

Tsuge, Masataka ^{[1
]}

Hiramatsu, Akira ^{[1
]}

Imamura, Michio ^{[1
]}

Kawakami, Yoshiiku ^{[1
]}

Masaki, Keiichi ^{[2
]}

Honda, Yoji ^{[3
]}

Mori, Nami ^{[3
]}

Takaki, Shintaro ^{[3
]}

Tsuji, Keiji ^{[3
]}

Kohno, Hirotaka ^{[4
]}

Kohno, Hiroshi ^{[4
]}

Moriya, Takashi ^{[5
]}

Nonaka, Michihiro ^{[6
]}

Hyogo, Hideyuki ^{[6
]}

Aisaka, Yasuyuki ^{[6
]}

Kimura, Tomoki ^{[7
]}

Nagata, Yasushi ^{[7
]}

Chayama, Kazuaki ^{[1
]}

机构：

[1] Hiroshima Univ, Div Frontier Med Sci, Dept Med & Mol Sci, Hiroshima, Japan

[2] Hiroshima City Asa Hosp, Hiroshima, Japan

[3] Hiroshima Red Cross Hosp, Hiroshima, Japan

[4] Kure Med Ctr, Hiroshima, Japan

[5] Chugoku Rousai Hosp, Hiroshima, Japan

[6] Hiroshima Gen Hosp, Hiroshima, Japan

[7] Hiroshima Univ Hosp, Dept Radiat Oncol, Hiroshima, Japan

来源：

ONCOLOGY | 2018年 / 94卷 / 04期

基金：

日本学术振兴会;

关键词：

Hepatocellular carcinoma; Sorafenib; Hepatic arterial infusion chemotherapy; Radiotherapy; SUBCUTANEOUS INTERFERON-ALPHA; INTRAARTERIAL; 5-FLUOROURACIL; COMBINATION THERAPY; MONOTHERAPY; CRITERIA; VERSION; TRIAL;

D O I：

10.1159/000486483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To compare the outcome of hepatic arterial infusion chemotherapy combined with radiotherapy (HAIC + RT) versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma (HCC) and major portal vein tumor thrombosis (PVTT). Methods: This retrospective study included 108 HCC patients with PVTT of the main trunk or first branch and Child-Pugh <= 7. Sixty-eight received HAIC + RT and 40 received sorafenib. Patients were then as-signed to the HAIC + RT group (n = 36) and the sorafenib group (n = 36) through case-control matching. The decision to treat with HAIC + RT or sorafenib was left to the attending physician. Results: The median overall, progression-free, and postprogression survival were significantly longer in the HAIC + RT group than in the sorafenib group (9.9 vs. 5.3, p = 0.002; 3.9 vs. 2.1, p = 0.048; and 3.7 vs. 1.9 months, p = 0.02, respectively). Multivariate analysis identified HAIC + RT (hazard ratio = 2.02; 95% confidence interval, 1.14-3.57; p = 0.01) as a significant and independent determinant of overall survival. Conclusions: In patients with advanced HCC and major PVTT, survival was significantly longer in those treated with HAIC + RT than with sorafenib. (C) 2018 S. Karger AG, Basel

引用

页码：215 / 222

页数：8

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