Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation

被引：43
作者：
Mahmoud, Marwa [1 ,2 ]
Abu-Shahba, Nourhan [1 ,2 ]
Azmy, Osama [1 ,3 ]
El-Badri, Nagwa [4 ]
机构：
[1] Natl Res Ctr, Med Res Ctr Excellence, Stem Cell Res Grp, Cairo 12411, Egypt
[2] Natl Res Ctr, Human Genet & Genome Res Div, Med Mol Genet Dept, Cairo 12411, Egypt
[3] Natl Res Ctr, Dept Reprod Hlth Res, Cairo 12411, Egypt
[4] Zewail City Sci & Technol, Ctr Excellence Stem Cells & Regenerat Med, Giza 12566, Egypt
来源：
STEM CELL REVIEWS AND REPORTS | 2019年 / 15卷 / 02期
关键词：
Diabetes mellitus; Mesenchymal stromal cells; Biology; Functionality; Autologus transplantation; HUMAN ADIPOSE-TISSUE; HEMATOPOIETIC STEM-CELLS; INSULIN-PRODUCING CELLS; HIGH GLUCOSE; BONE-MARROW; OSTEOGENIC DIFFERENTIATION; PERIODONTAL-LIGAMENT; SIGNALING PATHWAY; STEM/STROMAL CELLS; ENDOTHELIAL-CELLS;
D O I：
10.1007/s12015-018-9869-y
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellitus (DM). Autologous MSCs are assumed to be favorable because patient-derived cells are readily available and do not entail sustained immunosuppressive therapy. DM is associated with hyperglycemia, oxidative stress and altered immune responses and inflammation. It may thus alter the biological characteristics and therapeutic qualities of human MSCs (hMSCs). Several studies have explored the effect of DM or the diabetic microenvironment on the engraftment and efficacy of transplanted MSCs, which are determined by proliferation, differentiation, senescence, angiogenesis supportive effect, migration, anti-oxidative capacity and immunomodulatory properties. This review aims to present the available data on how DM impacts MSC biology and functionality and identify future perspectives for autologous MSC-based therapy in diabetics.
引用
收藏
页码：194 / 217
页数：24
相关论文
共 168 条
[1]   Adipose Mesenchymal Stromal Cells Isolated From Type 2 Diabetic Patients Display Reduced Fibrinolytic Activity [J].
Acosta, Lourdes ;
Hmadcha, Abdelkrim ;
Escacena, Natalia ;
Perez-Camacho, Inmaculada ;
de la Cuesta, Antonio ;
Ruiz-Salmeron, Rafael ;
Gauthier, Benoit R. ;
Soria, Bernat .
DIABETES, 2013, 62 (12) :4266-4269
[2]   High glucose induces adipogenic differentiation of muscle-derived stem cells [J].
Aguiari, Paola ;
Leo, Sara ;
Zavan, Barbara ;
Vindigni, Vincenzo ;
Rimessi, Alessandro ;
Bianchi, Katiuscia ;
Franzin, Chiara ;
Cortivo, Roberta ;
Rossato, Marco ;
Vettor, Roberto ;
Abatangelo, Giovanni ;
Pozzan, Tullio ;
Pinton, Paolo ;
Rizzuto, Rosario .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (04) :1226-1231
[3]  
Ali Fatima, 2017, Chronic Dis Transl Med, V3, P105, DOI 10.1016/j.cdtm.2017.02.006
[4]   The Effect of Chronic Inflammation and Oxidative and Endoplasmic Reticulum Stress in the Course of Metabolic Syndrome and Its Therapy [J].
Alicka, Michalina ;
Marycz, Krzysztof .
STEM CELLS INTERNATIONAL, 2018, 2018
[5]   Fibroblasts share mesenchymal phenotypes with stem cells, but lack their differentiation and colony-forming potential [J].
Alt, Eckhard ;
Yan, Yasheng ;
Gehmert, Sebastian ;
Song, Yao-Hua ;
Altman, Andrew ;
Gehmert, Sanga ;
Vykoukal, Daynene ;
Bai, Xiaowen .
BIOLOGY OF THE CELL, 2011, 103 (04) :197-208
[6]   Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration [J].
Alvarez-Perez, Juan Carlos ;
Ernst, Sara ;
Demirci, Cem ;
Casinelli, Gabriella P. ;
Mellado-Gil, Jose Manuel D. ;
Rausell-Palamos, Francisco ;
Vasavada, Rupangi C. ;
Garcia-Ocana, Adolfo .
DIABETES, 2014, 63 (01) :216-223
[7]   Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration [J].
Ambrosi, Thomas H. ;
Scialdone, Antonio ;
Graja, Antonia ;
Gohlke, Sabrina ;
Jank, Anne-Marie ;
Bocian, Carla ;
Woelk, Lena ;
Fan, Hua ;
Logan, Darren W. ;
Schuermann, Annette ;
Saraiva, Luis R. ;
Schulz, Tim J. .
CELL STEM CELL, 2017, 20 (06) :771-+
[8]   The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review [J].
Atashi, Fatemeh ;
Modarressi, Ali ;
Pepper, Michael S. .
STEM CELLS AND DEVELOPMENT, 2015, 24 (10) :1150-1163
[9]  
Atkinson MA, 2012, COLD SPRING HARB PER, V2, P2
[10]   PAT-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin [J].
Bajou, Khalid ;
Herkenne, Stephanie ;
Thijssen, Victor L. ;
D'Amico, Salvino ;
Ngoc-Quynh-Nhu Nguyen ;
Bouche, Ann ;
Tabruyn, Sebastien ;
Srahna, Mohammed ;
Carabin, Jean-Yves ;
Nivelles, Olivier ;
Paques, Cecile ;
Cornelissen, Ivo ;
Lion, Michelle ;
Noel, Agnes ;
Gils, Ann ;
Vinckier, Stefan ;
Declerck, Paul J. ;
Griffioen, Arjan W. ;
Dewerchin, Mieke ;
Martial, Joseph A. ;
Carmeliet, Peter ;
Struman, Ingrid .
NATURE MEDICINE, 2014, 20 (07) :741-747
12345678910