Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway

被引：33

作者：

Wang, Zhaohong ^{[1
]}

Guo, Jun ^{[2
]}

机构：

[1] Xuzhou Cent Hosp, Dept Orthoped, Xuzhou 221009, Jiangsu, Peoples R China

[2] Chongqing Med Univ, Dept Bone Trauma, Chongqing 400016, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2013年 / 67卷 / 02期

关键词：

BMP-7; Osteocyte; Apoptosis; GSK3; beta; BONE MORPHOGENETIC PROTEIN; SMOOTH-MUSCLE-CELLS; SIGNALING PATHWAYS; II RECEPTOR; DIFFERENTIATION; MECHANOTRANSDUCTION; PROLIFERATION; OSTEOPOROSIS; PREVENTION; MIGRATION;

D O I：

10.1007/s12013-013-9543-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mechanical loading is known to promote osteocyte survival, whereas glucocorticoid treatment results in osteocyte apoptosis. Here, we report that BMP-7, which was secreted by osteocyte in response to mechanical loading, exerts anti-apoptotic effect against dexamethasone-induced apoptosis of osteocytes. We further show that the anti-apoptotic effect of BMP-7 is mainly mediated through receptor BMPR2 and is associated with the activation of PI3K/AKT/GSK3 beta pathway.

引用

页码：567 / 574

页数：8

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