A Sequential One-Pot Protocol for the Synthesis of Dihydrobenzo[6,7]indolo[3′,4′:3,4,5]azepino[2,1-a]isoquinolines Using a Gold-Silver Combined Catalyst

被引：13

作者：

Saifuddin, Mohammad ^{[1
]}

Samala, Srinivas ^{[1
]}

Krishna, Deevi G. Venkata ^{[2
]}

Kundu, Bijoy ^{[1
,2
,3
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] CSIR Cent Drug Res Inst, Sophisticated Analyt & Instrumental Facil, Lucknow 226001, Uttar Pradesh, India

[3] Acad Sci & Innovat Res, New Delhi, India

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 11期

关键词：

polyheterocycles; alkyne; indole; annulation; Lewis acid; regioselective; PICTET-SPENGLER REACTION; PROTEIN-KINASE-C; ISOQUINOLINE ALKALOIDS; CYCLOISOMERIZATION REACTIONS; 1,3-DIPOLAR CYCLOADDITION; BETA-PHENYLETHYLAMINES; 3-COMPONENT REACTION; INTERNAL ALKYNES; TERMINAL ALKYNES; TANDEM SYNTHESIS;

D O I：

10.1055/s-0033-1338424

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A sequential one-pot protocol for the synthesis of indole-based peri-annulated polyheterocycles using trifluoroacetic acid and a gold-silver combined catalyst system is described. The reaction is thought to proceed via an imine formation-cationic pi-cyclization-alkyne activation-intramolecular hydroamination sequence to yield novel dihydrobenzo[6,7]indolo[3',4':3,4,5]azepino[2,1-a]isoquinolines in good yields.

引用

页码：1553 / 1563

页数：11

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