Evaluation of TSH cutoff value in blood-spot samples in neonatal screening for the diagnosis of congenital hypothyroidism in the Programa "Primeiros Passos" - IEDE/RJ

被引：7

作者：

Barone, Bianca ^{[1
]}

da Silva Lopes, Clarisse Lourandes ^{[1
]}

Tyszler, Latife Salomao ^{[1
]}

do Amaral, Valeria Borges ^{[1
]}

Zarur, Rosa Helena C. ^{[1
]}

Paiva, Valeria Neto ^{[1
]}

Leite, Denise Boechat ^{[1
]}

Meirelles, Ricardo M. R. ^{[1
]}

机构：

[1] Inst Estadual Diabet & Endocrinol Luiz Capriglion, Programa Primeiros Passos, Rio De Janeiro, RJ, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2013年 / 57卷 / 01期

关键词：

Congenital hypothyroidism; neonatal screening; TSH; congenital diseases; MANAGEMENT; INFANTS; UPDATE;

D O I：

10.1590/S0004-27302013000100008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To analyze the confirmed or not-confirmed cases of neonatal screening (CH) screened in the Programa "Primeiros Passos", stratifying them into TSH blood-spot (TSH-BS) ranges. Materials and methods: To stratify, in ranges of TSH-BS as a function of TSH serum (TSH-S), the cases called for a confirmatory test from January, 2006 to July, 2009. Results: Around 37% of the confirmed cases (475) showed TSH-F >= 9.5 mUi/L, but most of the confirmed cases were in lower TSH-F ranges. Among the unconfirmed cases (4,613), most were found in the lower ranges. There was no TSH-F range exclusive to unconfirmed cases. Conclusion: TSH-BS cutoff value used is crucial in the diagnosis of CH and should be low, even if more confirmatory tests are performed. More studies are needed to determine the best cutoff value of TSH-BS for neonatal screening. Arq Bras Endocrinol Metab. 2013;57(1):57-61

引用

页码：57 / 61

页数：5

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