Biophysical Insights into How Lipid Membranes Modulate Huntingtin Aggregation Associated with Huntington's Disease

被引：0
|
作者：
Legleiter, Justin [1 ]
机构：
[1] West Virginia Univ, Dept Chem, Morgantown, WV 26506 USA
来源：
BIOPHYSICAL JOURNAL | 2019年 / 116卷 / 03期
关键词：
D O I：
10.1016/j.bpj.2018.11.2674
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2457-Pos
引用
收藏
页码：496A / 496A
页数：1
相关论文
共 50 条
  • [11] Huntingtin Aggregation Is Modified in the Presence of a Variety of Lipid Membranes
    Beasley, Maryssa A.
    Groover, Sharon E.
    Legleiter, Justin A.
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 455A - 455A
  • [12] Curvature Enhances Binding and Aggregation of Huntingtin at Lipid Membranes
    Chaibva, Maxmore
    Burke, Kathleen A.
    Legleiter, Justin
    BIOCHEMISTRY, 2014, 53 (14) : 2355 - 2365
  • [13] Huntington disease: new insights on the role of huntingtin cleavage
    Wellington, CL
    Leavitt, BR
    Hayden, MR
    JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, 2000, (58): : 1 - 17
  • [14] Huntington disease: new insights on the role of huntingtin cleavage
    Wellington, CL
    Leavitt, BR
    Hayden, MR
    ADVANCES IN RESEARCH ON NEURODEGENERATION, VOL 7, 2000, 7 : 1 - 17
  • [15] Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models
    Sontag, Emily Mitchell
    Lotz, Gregor P.
    Agrawal, Namita
    Tran, Andrew
    Aron, Rebecca
    Yang, Guocheng
    Necula, Mihaela
    Lau, Alice
    Finkbeiner, Steven
    Glabe, Charles
    Marsh, J. Lawrence
    Muchowski, Paul J.
    Thompson, Leslie M.
    JOURNAL OF NEUROSCIENCE, 2012, 32 (32): : 11109 - 11119
  • [16] Huntingtin is associated with intracellular neuropathology in Huntington's, Alzheimer's and Pick's disease
    Singhrao, SK
    Thomas, P
    Wood, JD
    Harper, PS
    Neal, JW
    Jones, AL
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : A321 - A321
  • [17] Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes
    Gao, Xiang
    Campbell, Warren A.
    Chaibva, Maxmore
    Jain, Pranav
    Leslie, Ashley E.
    Frey, Shelli L.
    Legleiter, Justin
    BIOCHEMISTRY, 2016, 55 (01) : 92 - 102
  • [18] Huntingtin Aggregation and Lipid Binding are Influenced by Physicochemical Properties of Membranes
    Beasley, Maryssa
    Groover, Sharon E.
    Frazee, Nicolas C.
    Mertz, Blake
    Valentine, Stephen J.
    Legleiter, Justin A.
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 59A - 59A
  • [19] Aggregation State of Huntingtin Regulates Its Interaction with Lipid Membranes
    Sedighi, Faezeh
    Adegbuyiro, Adewale
    Legleiter, Justin A.
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 540A - 540A
  • [20] Interaction of huntingtin fragments with brain membranes -: clues to early dysfunction in Huntington's disease
    Suopanki, J
    Götz, C
    Lutsch, G
    Schiller, J
    Harjes, P
    Herrmann, A
    Wanker, EE
    JOURNAL OF NEUROCHEMISTRY, 2006, 96 (03) : 870 - 884
12345