Estradiol decreases blood pressure in association with redox regulation in preeclampsia

被引:12
作者
Babic, Goran M. [1 ,2 ]
Markovic, Snezana D. [3 ]
Varjacic, Mirjana [1 ,2 ]
Djordjevic, Natasa Z. [4 ]
Nikolic, Tamara [5 ]
Stojic, Isidora [5 ]
Jakovljevic, Vladimir [6 ,7 ]
机构
[1] Univ Kragujevac, Fac Med Sci, Kragujevac, Serbia
[2] Clin Ctr Kragujevac, Dept Obstet & Gynecol, Kragujevac, Serbia
[3] Univ Kragujevac, Inst Biol & Ecol, Fac Sci, Kragujevac, Serbia
[4] State Univ Novi Pazar, Dept Biomed Sci, Novi Pazar, Serbia
[5] Univ Kragujevac, Dept Pharm, Fac Med Sci, Kragujevac, Serbia
[6] Univ Kragujevac, Dept Physiol, Fac Med Sci, Serbia Svetozara Markovica 69,POB 124, Kragujevac 34000, Serbia
[7] 1st Moscow State Med Univ IM Sechenov, Dept Human Pathol, Trubetskaya St 8,Str 2, Moscow 119991, Russia
关键词
Estradiol; hypertension; oxidative stress; preeclampsia; vascular dysfunction; ESTROGEN REPLACEMENT THERAPY; NITRIC-OXIDE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; SEX-HORMONES; EXPRESSION; PLASMA; 17-BETA-ESTRADIOL; PEROXYNITRITE; MODULATION;
D O I
10.1080/10641963.2017.1368538
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this study, we tested a hypothesis that a short-term estradiol therapy may reduce blood pressure in preeclampsia by modulating plasma oxidative stress. The intramuscular injections of 10mg 17-beta-estradiol were prescribed to preeclamptic pregnant women during the 3-day therapy before a labor induction. The analyses of mean arterial pressure (MAP), serum estradiol concentrations, plasma superoxide anion (O-2.), hydrogen peroxide (H2O2), nitrites (NO2-), and peroxynitrite (ONOO-) were conducted before and during the therapy. We found that the plasma concentrations of oxidative stress markers, such as O-2(-) and H2O2, are higher in preeclampsia and positively correlated with the MAP value. Moreover, it was shown that the plasma concentration of NO2- as an indicator of NO levels is higher in preeclampsia. A short-term intramuscular application of estradiol decreases the MAP value and the plasma concentration of O.-, H2O2, NO2-, and ONOO- in preeclampsia. A positive correlation between the decrease of MAP values and the decrease of plasma concentrations of O-2(-), H2O2, and ONOO- was found in preeclampsia during a short-term estradiol therapy. We conclude that the short-term estradiol therapy decreases the MAP value in preeclampsia by modulating the plasma oxidative stress. We speculate that the estradiol metabolism in preeclampsia is an important mechanism that contributes to vascular dysfunction.
引用
收藏
页码:281 / 286
页数:6
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