Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series

被引：96

作者：

Doi, Kent ^{[1
]}

Ikeda, Mahoko ^{[2
]}

Hayase, Naoki ^{[1
]}

Moriya, Kyoji ^{[2
,3
]}

Morimura, Naoto ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Acute Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Univ Tokyo Hosp, Dept Infect Control & Prevent, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Infect Dis, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[4] Univ Tokyo, Grad Sch Med, Senior Prof Off, Tokyo, Japan

来源：

CRITICAL CARE | 2020年 / 24卷 / 01期

关键词：

D O I：

10.1186/s13054-020-03078-z

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

[No abstract available]

引用

页数：4

共 5 条

[1] SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor [J].

Hoffmann, Markus ;

Kleine-Weber, Hannah ;

Schroeder, Simon ;

Krueger, Nadine ;

Herrler, Tanja ;

Erichsen, Sandra ;

Schiergens, Tobias S. ;

Herrler, Georg ;

Wu, Nai-Huei ;

Nitsche, Andreas ;

Mueller, Marcel A. ;

Drosten, Christian ;

Poehlmann, Stefan .

CELL, 2020, 181 (02) :271-+

[2] Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19 [J].

Hoffmann, Markus ;

Schroeder, Simon ;

Kleine-Weber, Hannah ;

Mueller, Marcel A. ;

Drosten, Christian ;

Poehlmann, Stefan .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (06)

[3] Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia [J].

McGonagle, Dennis ;

O'Donnell, James S. ;

Sharif, Kassem ;

Emery, Paul ;

Bridgewood, Charles .

LANCET RHEUMATOLOGY, 2020, 2 (07) :E437-E445

[4]

Yamamoto M, 2020, BIORXIV

[5] Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay [J].

Yamamoto, Mizuki ;

Matsuyama, Shutoku ;

Li, Xiao ;

Takeda, Makoto ;

Kawaguchi, Yasushi ;

Inoue, Jun-ichiro ;

Matsuda, Zene .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (11) :6532-6539

← 1 →