Antibacterial activities of novel diselenide-bridged bis(Porphyrin)s on Staphylococcus aureus investigated by microcalorimetry

被引：24

作者：

Xu, Xiang-jiao ^{[1
,2
]}

Xue, Zhi ^{[1
]}

Xiao, Qi ^{[1
]}

Hou, An Xin ^{[1
]}

Liu, Yi ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, State Key Lab Virol, Wuhan 430072, Peoples R China

[2] Wuhan Univ Sci & Technol, Coll Chem Engn & Technol, Wuhan 430081, Hubei, Peoples R China

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2008年 / 125卷 / 02期

基金：

中国国家自然科学基金;

关键词：

diselenide-bridged bis(porphyrin)s; Staphylococcus aureus; antibacterial activities; microcalorimetry; thermokinetics;

D O I：

10.1007/s12011-008-8156-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The actions of two novel diselenide-bridged bis(porphyrin)s (1 and 2) on Staphylococcus aureus growth was investigated by microcalorimetry at 37.00 degrees C, compared with that of Na2SeO3. Differences in their capacities to inhibit the growth metabolism of S. aureus were observed. By analyzing the power-time curves, crucial parameters such as the rate constant of bacterial growth (k), inhibitory rate (I), and generation time (t(G)) were determined. The growth rate constant (k) of S. aureus (in the log phase) in the presence of the drugs decreased with increasing concentrations of the drugs regularly. The relationship of k and c is nearly linear for diselenide-bridged bis(porphyrin) 2. The sequence of the antibacterial activities of these selenium compounds tested was 2>1>Na2SeO3.

引用

页码：185 / 192

页数：8

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