Pharmacologically intractable epilepsy in children: diagnosis and preoperative evaluation

被引：35
作者：
Go, Cristina
Snead, O. Carter, III [1 ]
机构：
[1] Hosp Sick Children, Div Neurol, Toronto, ON M5G 1X8, Canada
来源：
NEUROSURGICAL FOCUS | 2008年 / 25卷 / 03期
关键词：
epilepsy surgery; medically intractable epilepsy; presurgical evaluation;
D O I：
10.3171/FOC/2008/25/9/E2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
It is important to correctly diagnose medically intractable epilepsy in children and to identify those children whose medically refractory, localization-related seizures may be surgically remediable as soon as possible to optimize the surgical outcome. In this paper the authors review the definition of medically intractable seizures and discuss the various causes and risk factors for this disorder in children. They also outline the presurgical diagnostic evaluation process for pharmacologically intractable epilepsy in children who may be candidates for surgical treatment of localization-related seizures. The treatment of children with medically intractable epilepsy is both challenging and rewarding. Surgery has the potential of altering the natural history of epilepsy by improving or eliminating seizures in carefully selected patients.
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页数：7
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共 75 条
[1]  
ADELSON PD, 1995, NEUROSURG CLIN N AM, V6, P491
[2]   The relative influence of epileptic EEG discharges, short nonconvulsive seizures, and type of epilepsy on cognitive function [J].
Aldenkamp, T ;
Arends, T .
EPILEPSIA, 2004, 45 (01) :54-63
[3]   fMRI lateralization of expressive language in children with cerebral lesions [J].
Anderson, Dianne P. ;
Harvey, A. Simon ;
Saling, Michael M. ;
Anderson, Vicki ;
Kean, Michael ;
Abbott, David F. ;
Wellard, R. Mark ;
Jackson, Graeme D. .
EPILEPSIA, 2006, 47 (06) :998-1008
[4]   The early prognosis of epilepsy in childhood: The prediction of a poor outcome. The Dutch study of epilepsy in childhood [J].
Arts, WFM ;
Geerts, AT ;
Brouwer, OF ;
Peters, ACB ;
Stroink, H ;
van Donselaar, CA .
EPILEPSIA, 1999, 40 (06) :726-734
[5]   Limitations in the medical treatment of cryptogenic or symptomatic localization-related epilepsies of childhood onset [J].
Aso, K ;
Watanabe, K .
EPILEPSIA, 2000, 41 :18-20
[6]   Is tolerance to antiepileptic drugs clinically relevant? [J].
Avanzini, Giuliano .
EPILEPSIA, 2006, 47 (08) :1285-1287
[7]  
Barkovich AJ, 1997, EPILEPSIA, V38, P1255
[8]   Classification system for malformations of cortical development - Update 2001 [J].
Barkovich, AJ ;
Kuzniecky, RI ;
Jackson, GD ;
Guerrini, R ;
Dobyns, WB .
NEUROLOGY, 2001, 57 (12) :2168-2178
[9]  
BENBADIS SR, 2001, TREATMENT EPILEPSY P, P1067
[10]   Multiple subpial transections in pediatric epilepsy: indications and outcomes [J].
Benifla, Mony ;
Otsubo, Hiroshi ;
Ochi, Ayako ;
Snead, O. Carter, III ;
Rutka, James T. .
CHILDS NERVOUS SYSTEM, 2006, 22 (08) :992-998
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