Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction

被引：22

作者：

Abbas, Muhammad ^{[1
,2
]}

Wessjohann, Ludger A. ^{[1
]}

机构：

[1] Leibniz Inst Pflanzenbiochem, D-06120 Halle, Saale, Germany

[2] King Saud Univ, Dept Zool, Fac Sci, Chair Adv Prote & Cytom Res, Riyadh 11415, Saudi Arabia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 47期

关键词：

GLUTATHIONE-PEROXIDASE; CONVERTIBLE ISONITRILE; MAMMALIAN THIOREDOXIN; SELENIUM; DISELENIDE; OXIDATION; DERIVATIVES; CHEMISTRY; MECHANISM; EMPHASIS;

D O I：

10.1039/c2ob26552d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ammonia and selenoaldehydes are both problematic components in Ugi reactions. Here we report the efficient direct multicomponent synthesis of sensitive selenocysteine peptides without the use of convertible (protected) primary amines, including suitable deprotection protocols for selenols.

引用

页码：9330 / 9333

页数：4

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